@article { , title = {Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch}, abstract = {While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. Results indicate that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch, in line with previous findings. Skin warming increased cowhage-induced itch intensity. Potential mechanisms of this interaction between thermosensation and pruritoception could involve cold-sensitive channels such as TRPM8, TREK-1 or TRPC5 in the case of histamine. The rapid modulation of cowhage induced itch - but not histamine-induced itch - by transient skin warming could be related to the lower temperature threshold of pruriceptive polymodal C-fibres (cowhage) as compared to the higher temperature threshold of the mechanoinsensitive C-Fibres conveying histaminergic itch.}, doi = {10.2340/00015555-3077}, eissn = {1651-2057}, issn = {0001-5555}, issue = {2}, note = {Add published version when available}, pages = {188-195}, publicationstatus = {Published}, publisher = {Society for Publication of Acta Dermato-Venereologica}, url = {https://hull-repository.worktribe.com/output/1134009}, volume = {99}, keyword = {Cognitive and Clinical Neuroscience, Health and Health Inequalities, Skin temperature, Histamine, Sensory thresholds, Pruritus}, year = {2019}, author = {Lewis, Z and George, David N and Cowdell, Fiona and Holle, Henning} }