@article { , title = {Hyperpolarisation through reversible interactions with parahydrogen}, abstract = {We describe here how the complexes Ir(COD)(NHC)Cl [NHC = IMes, SIMes, IPr, SIPr, ICy, IMe and ImMe2NPri2] provide significant insight into the catalytic process that underpins the hyperpolarization method signal amplification by reversible exchange (SABRE). These complexes react with pyridine and H2 to produce [Ir(H)2(NHC)(py)3]Cl which undergo ligand exchange on a timescale commensurate with good catalytic activity for the signal amplification by reversible exchange effect. This activity results from hydride ligand magnetic inequivalence and is highly dependent on the NHC. Variable temperature and kinetic studies demonstrate that rates of ligand loss which lie between 0.1 and 0.5 s−1 are ideal for catalysis. A role for the solvent complex [Ir(H)2(MeOH)(NHC)(py)2]Cl, which contains chemically inequivalent hydride ligands is revealed in the ligand exchange pathway. By optimisation of the conditions and NHC, a 5500-fold total pyridine signal enhancement is revealed when the NHC is IMes. Both T1-reduction effects and HD exchange with the solvent are probed and shown to link to catalyst efficiency. The resulting signal enhancements suggest future in vivo MRI measurements under physiological conditions using this catalytic effect will be possible.}, doi = {10.1039/c4cy00464g}, eissn = {2044-4761}, issn = {2044-4753}, issue = {10}, journal = {Catalysis Science and Technology}, pages = {3544-3554}, publicationstatus = {Published}, publisher = {Royal Society of Chemistry}, url = {https://hull-repository.worktribe.com/output/1563135}, volume = {4}, keyword = {Health and Health Inequalities}, year = {2014}, author = {Lloyd, Lyrelle S. and Asghar, Aziz and Burns, Michael J. and Charlton, Adrian and Coombes, Steven and Cowley, Michael J. and Dear, Gordon J. and Duckett, Simon B. and Genov, Georgi R. and Green, Gary G. R. and Highton, Louise A. R. and Hooper, Alexander J. J. and Khan, Majid and Khazal, Iman G. and Lewis, Richard. J. and Mewis, Ryan E. and Roberts, Andrew D. and Ruddlesden, Amy J.} }