@article { , title = {Effects of novel antidiabetes agents on apoptotic processes in diabetes and malignancy: Implications for lowering tissue damage}, abstract = {Apoptosis is a complicated process that involves activation of a series of intracellular signaling. Tissue injuries from diabetes mellitus mostly occur as a consequence of higher rate of apoptosis process due to activation of a series of molecular mechanisms. Several classes of anti-hyperglycaemic agents have been developed which could potentially modulate the apoptotic process resulting in fewer tissue damages. Novel types of anti-hyperglycaemic medications such as sodium glucose cotransporters-2 inhibitors, glucagon like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors have shown to provide potent anti-hyperglycaemic effects, but their influences on diabetes-induced apoptotic injuries is largely unknown. Therefore, in the current study, we reviewed the published data about the possible effects of these anti-hyperglycaemic agents on apoptosis in diabetic milieu as well as in cancer cells.}, doi = {10.1016/j.lfs.2019.06.013}, eissn = {1879-0631}, issn = {0024-3205}, journal = {Life Sciences}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://hull-repository.worktribe.com/output/1964125}, volume = {231}, keyword = {Health and Health Inequalities, SGLT2 inhibitor, GLP-1 receptor agonist, DPP-4 inhibitor, Oxidative stress, Apoptosis, Diabetes mellitus, Caspase, Cancer}, year = {2019}, author = {Sathyapalan, Thozhukat and Yaribeygi, Habib and Sahebkar, Amirhossein and Lhaf, Fadel} }