@article { , title = {The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms}, abstract = {C-peptide is a small peptide connecting two chains of proinsulin molecule and is dissociated before the release of insulin. It is secreted in an equimolar amount to insulin from the pancreatic beta-cells into the circulation. Recent evidence demonstrates that it has other physiologic activities beyond its structural function. C-peptide modulates intracellular signaling pathways in various pathophysiologic states and, could potentially be a new therapeutic target for different disorders including diabetic complications. There is growing evidence that c-peptide has modulatory effects on the molecular mechanisms involved in the development of diabetic nephropathy. Although we have little direct evidence, pharmacological properties of c-peptide suggest that it can provide potent renoprotective effects especially, in a c-peptide deficient milieu as in type 1 diabetes mellitus. In this review, we describe possible molecular mechanisms by which c-peptide may improve renal efficiency in a diabetic milieu.}, doi = {10.1016/j.lfs.2019.116950}, eissn = {1879-0631}, issn = {0024-3205}, journal = {Life Sciences}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://hull-repository.worktribe.com/output/2975798}, volume = {237}, keyword = {Health and Health Inequalities, Diabetes mellitus, Diabetic nephropathy, C-peptide, Oxidative stress, NF-κB, Nitric oxide}, year = {2019}, author = {Yaribeygi, Habib and Maleki, Mina and Sathyapalan, Thozhukat and Sahebkar, Amirhossein} }