@article { , title = {Water-Soluble Rhenium Phosphine Complexes Incorporating the Ph2C(X) Motif (X = O–, NH–): Structural and Cytotoxicity Studies}, abstract = {Reaction of [ReOCl3(PPh3)2] or [ReO2I(PPh3)2] with 2,2′-diphenylglycine (dpgH2) in refluxing ethanol afforded the air-stable complex [ReO(dpgH)(dpg)(PPh3)] (1). Treatment of [ReO(OEt)I2(PPh3)2] with 1,2,3-triaza-7-phosphaadamantane (PTA) afforded the complex [ReO(OEt)I2(PTA)2] (2). Reaction of [ReOI2(PTA)3] with dpgH2 led to the isolation of the complex [Re(NCPh2)I2(PTA)3]·0.5EtOH (3·0.5EtOH). A similar reaction but using [ReOX2(PTA)3] (X = Cl, Br) resulted in the analogous halide complexes [Re(NCPh2)Cl2(PTA)3]·2EtOH (4·2EtOH) and [Re(NCPh2)(PTA)3Br2]·1.6EtOH (5·1.6EtOH). Using benzilic acid (2,2′-diphenylglycolic acid, benzH) with 2 afforded the complex [ReO(benz)2(PTA)][PTAH]·EtOH (6·EtOH). The potential for the formation of complexes using radioisotopes with relatively short half-lives suitable for nuclear medicine applications by developing conditions for [Re(NCPh2)(dpg)I(PTA)3] (7)[ReO4]− in a 4 h time scale was investigated. A procedure for the technetium analog of complex [Re(NCPh2)I2(PTA)3] (3) from 99mTc[TcO4]− was then investigated. The molecular structures of 1–7 are reported; complexes 3–7 have been studied using in vitro cell assays (HeLa, HCT116, HT-29, and HEK 293) and were found to have IC50 values in the range of 29–1858 μM.}, doi = {10.1021/acs.inorgchem.9b03239}, eissn = {1520-510X}, issn = {0020-1669}, issue = {4}, journal = {Inorganic chemistry}, pages = {2367-2378}, publicationstatus = {Published}, publisher = {American Chemical Society}, url = {https://hull-repository.worktribe.com/output/3394214}, volume = {59}, keyword = {Chemistry for Sustainability, Hull Molecular Imaging Centre, Energy, Environment and Sustainability, Rhenium, Ligands, Crystal structure, Ethanol, Mixtures}, year = {2020}, author = {Alshamrani, Abdullah F. and Prior, Timothy J. and Burke, Benjamin P. and Roberts, David P. and Archibald, Stephen J. and Higham, Lee J. and Stasiuk, Graeme and Redshaw, Carl} }