@article { , title = {Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention}, abstract = {Duchenne Muscular Dystrophy is a devastating disease caused by the absence of a functional rod-shaped cytoplasmic protein called dystrophin. Several avenues are being developed aimed to restore dystrophin expression in boys affected by this X-linked disease. However, its complete cure is likely to need combinational approaches which may include regimes aimed at restoring muscle mass. Augmenting muscle growth through the manipulation of the Myostatin/Activin signalling axis has received much attention. However, we have recently shown that while manipulation of this axis in wild type mice using the sActRIIB ligand trap indeed results in muscle growth, it also had a detrimental impact on the testis. Here we examined the impact of administering a powerful Myostatin/Activin antagonist in two mouse models of Duchenne Muscular Dystrophy. We report that whilst the impact on muscle growth was not always positive, both models showed attenuated testis development. Sperm number, motility and ultrastructure were significantly affected by the sActRIIB treatment. Our report suggests that interventions based on Myostatin/Activin should investigate off-target effects on tissues as well as muscle.}, doi = {10.4081/ejtm.0.8904}, issn = {2037-7452}, issue = {2}, journal = {European Journal of Translational Myology}, note = {-1 - This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (CC BY-NC 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.}, pages = {276-285}, publicationstatus = {Published}, publisher = {PAGEpress}, url = {https://hull-repository.worktribe.com/output/3475131}, volume = {30}, keyword = {Health and Health Inequalities, Duchenne Muscular Dystrophy, Mdx, Muscle hypertrophy, Testis, Activin, Myostatin}, author = {Vaughan, Danielle and Kretz, Oliver and Alqallaf, Ali and Mitchell, Robert and von der Heide, Jenny and Vaiyapuri, Sakthivel and Matsakas, Antonios and Pasternack, Arja and Collins-Hooper, Henry and Ritvos, Olli and Ballesteros, Randy and Huber, Tobias B. and Amthor, Helge and Mukherjee, Abir and Patel, Ketan} }