@article { , title = {Cough persistence in adults with chronic cough: a 4-year retrospective cohort study}, abstract = {Background There is very limited evidence regarding long-term prognosis of chronic cough. We examined longitudinal outcomes among patients with chronic cough, and explored predictors of cough persistence. Methods A retrospective cohort was constructed of adults who had newly visited a specialist cough clinic in 2012–2013. All had undergone systematic investigation for chronic cough. The Hull Airway Reflux Questionnaire (HARQ) was administered to assess reflux cough symptoms. A follow-up survey was conducted in 2016–2017 to assess cough persistence. Results From 418 candidates, 323 participated in the follow-up study; main analyses focused on patients with chronic persistent cough (n=64; 19.8\%) and remitted cough (n=193; 59.8\%). Compared with remitted cough, chronic persistent cough group had more family history of chronic cough (17.2\% vs. 4.7\%, p=0.001) and cold air-sensitive cough (62.5\% vs. 44.6\%, p=0.013). The total HARQ score did not differ; however, two items (cough with eating and cough with certain foods) scored significantly higher in chronic persistent cough. In multivariate analyses, a family history of chronic cough (adjusted odds ratio 4.27 [95\% confidence interval 1.35-9.89]), cold air-sensitive cough (2.01 [1.09-3.73]), and cough with eating (1.22 [1.02–1.45]) were associated with chronic persistent cough at 4 years. Conclusions Cough persists in about 20\% of patients after 4 years following systematic assessment and treatments. Several cough characteristics, such as family history, cold air-sensitivity, or reflux cough, may be associated with cough persistence. Larger cohort studies are warranted to further understand long-term prognosis and confirm predictors of persistence in patients with chronic cough.}, doi = {10.1016/j.alit.2020.03.012}, eissn = {1440-1592}, issn = {1323-8930}, issue = {4}, journal = {Allergology International}, pages = {588-593}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://hull-repository.worktribe.com/output/3481376}, volume = {69}, keyword = {Health and Health Inequalities, Chronic cough, Epidemiology, Longitudinal outcome, Predictor, Retrospective cohort study}, year = {2020}, author = {Kang, Sung Yoon and Song, Woo Jung and Won, Ha Kyeong and Chung, Soo Jie and Kim, Ju Young and Park, Heung Woo and Morice, Alyn H. and Cho, Sang-Heon} }