@article { , title = {Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study}, abstract = {Rationale: The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established.Objectives: To assess outcomes in patients with ILD hospitalized for COVID-19 versus those without ILD in a contemporaneous age-, sex-, and comorbidity-matched population.Methods: An international multicenter audit of patients with a prior diagnosis of ILD admitted to the hospital with COVID-19 between March 1 and May 1, 2020, was undertaken and compared with patients without ILD, obtained from the ISARIC4C (International Severe Acute Respiratory and Emerging Infection Consortium Coronavirus Clinical Characterisation Consortium) cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished idiopathic pulmonary fibrosis from non-idiopathic pulmonary fibrosis ILD and used lung function to determine the greatest risks of death.Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to the hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity score matching. Overall mortality was 49\% (79/161) in patients with ILD with COVID-19. After matching, patients with ILD with COVID-19 had significantly poorer survival (hazard ratio [HR], 1.60; confidence interval, 1.17-2.18; Pā€‰=ā€‰0.003) than age-, sex-, and comorbidity-matched controls without ILD. Patients with an FVC of}, doi = {10.1164/rccm.202007-2794OC}, eissn = {1535-4970}, issn = {1073-449X}, issue = {12}, journal = {American journal of respiratory and critical care medicine}, pages = {1656-1665}, publicationstatus = {Published}, publisher = {American Thoracic Society}, url = {https://hull-repository.worktribe.com/output/3632790}, volume = {202}, keyword = {Health and Health Inequalities, COVID-19, IPF, ILD, Obesity, Lung function, Hospitalisation}, year = {2020}, author = {Drake, Thomas M and Docherty, Annemarie B and Harrison, Ewen M and Quint, Jennifer K and Adamali, Huzaifa and Agnew, Sarah and Babu, Suresh and Barber, Christopher M and Barratt, Shaney and Bendstrup, Elisabeth and Bianchi, Stephen and Villegas, Diego Castillo and Chaudhuri, Nazia and Chua, Felix and Coker, Robina and Chang, William and Crawshaw, Anjali and Crowley, Louise E. and Dosanjh, Davinder and Fiddler, Christine A and Forrest, Ian A. and George, Peter M and Gibbons, Michael A and Groom, Katherine and Haney, Sarah and Hart, Simon P. and Heiden, Emily and Henry, Michael and Ho, Ling Pei and Hoyles, Rachel K and Hutchinson, John and Hurley, Killian and Jones, Mark G and Jones, Steve and Kokosi, Maria and Kreuter, Michael and Mackay, Laura S and Mahendran, Siva and Margaritopoulos, George and Molina-Molina, Maria and Molyneaux, Philip L and O'Brien, Aidan and O'Reilly, Katherine and Packham, Alice and Parfrey, Helen and Poletti, Venerino and Porter, Joanna C. and Renzoni, Elisabetta and Rivera-Ortega, Pilar and Russell, Anne Marie and Saini, Gauri and Spencer, Lisa G and Stella, Giulia M. and Stone, Helen and Sturney, Sharon and Thickett, David and Thillai, Muhunthan and Wallis, Tim and Ward, Katie and Wells, Athol U and West, Alex and Wickremasinghe, Melissa and Woodhead, Felix and Hearson, Glenn and Howard, Lucy and Baillie, J. Kenneth and Openshaw, Peter J.M. and Semple, Malcolm G and Stewart, Iain and Jenkins, R. Gisli and ISARIC4C Investigators,} }