@article { , title = {Salivary testosterone measurement in women with and without polycystic ovary syndrome}, abstract = {Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. salT and salA were significantly elevated in PCOS compared to controls (P<001). No androgen marker was more predictive than another using ROC curves, but multiple logistic regression suggested salT was more predictive than free androgen index (FAI)(p<0.01). The combination of salT or FAI identified 100\% of PCOS women. PCOS women with both biochemical and clinical hyperandrogenism as opposed to clinical hyperandrogenism alone showed a metabolic phenotype (p<0.05) and insulin resistance(p<0.001). PCOS patients with an isolated elevated FAI showed increased insulin resistance compared to those with an isolated salT(P<0.05). salT appeared to be at least as predictive as FAI for the diagnosis of the classical PCOS phenotype, and the combination of salT or FAI identified 100\% of PCOS patients. This suggests that salT measurement by LC-MS/MS holds the promise of complementing existing laboratory tests as a means of assessing hyperandrogenemia.}, doi = {10.1038/s41598-017-03945-w}, eissn = {2045-2322}, issn = {2045-2322}, issue = {1}, journal = {Scientific reports}, publicationstatus = {Published}, publisher = {Nature Publishing Group}, url = {https://hull-repository.worktribe.com/output/368776}, volume = {7}, keyword = {Health and Health Inequalities, Polycystic ovary syndrome, Testosterone}, year = {2017}, author = {Sathyapalan, Thozhukat and Al-Qaissi, Ahmed and Kilpatrick, Eric S. and Dargham, Soha R. and Adaway, Joanne and Keevil, Brian and Atkin, Stephen L.} }