@article { , title = {Conjugatable water-soluble Pt(ii) and Pd(ii) porphyrin complexes: Novel nano- and molecular probes for optical oxygen tension measurement in tissue engineering}, abstract = {Measurement of oxygen tension in compressed collagen sheets was performed using matrix-embedded optical oxygen sensors based on platinum(II) and palladium(II) porphyrins supported on polyacrylamide nanoparticles. Bespoke, fully water-soluble, mono-functionalised Pt(II) and Pd(II) porphyrin complexes designed for conjugation under mild conditions were obtained using microwave-assisted metallation. The new sensors display a linear response (1/τ vs. O₂) to varying oxygen tension over a biologically relevant range (7.0 × 10⁻⁴ to 2.7 × 10⁻¹ mM) in aqueous solutions; a behaviour that is maintained following conjugation to polyacrylamide nanoparticles, and following embedding of the nanosensors in compressed collagen sheets, paving the way to innovative approaches for real-time resolution of oxygen gradients throughout 3D matrices useful for tissue regeneration.}, doi = {10.1039/c4pp00026a}, eissn = {1474-9092}, issn = {1474-905X}, issue = {7}, journal = {Photochemical \& photobiological sciences}, pages = {1039-1051}, publicationstatus = {Published}, publisher = {Royal Society of Chemistry}, url = {https://hull-repository.worktribe.com/output/378261}, volume = {13}, keyword = {Specialist Research - Other, Oxygen tension, Porphyrin complexes , Tissue engineering}, year = {2014}, author = {Giuntini, F. and Chauhan, V. M. and Aylott, J. W. and Rosser, G. A. and Athanasiadis, A. and Beeby, A. and MacRobert, A. J. and Brown, R. A. and Boyle, R. W.} }