@article { , title = {Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water}, abstract = {Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) is the most frequently used radiotracer for the routine clinical evaluation of malignant tumors in a range of body tissues. FDG synthesis is continuously being developed to improve and simplify the synthetic procedure including the isolation of [ 18 F]fluoride from [ 18 O]water. There are many methods reported in literature for the isolation of [ 18 F]fluoride, including evaporation, coat-capture-elution, the use of cation-exchange resin and electrode trapping. This review article gives an overview of some of the most common methods for the separation of [ 18 F]fluoride ions from [ 18 O]water, highlighting the potential strength of the methods and also problems and weaknesses for synthesis of 18 F PET tracers. © 2014 Elsevier Ltd.}, doi = {10.1016/j.apradiso.2014.04.021}, eissn = {1872-9800}, issn = {0969-8043}, journal = {Applied Radiation and Isotopes}, pages = {64-70}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://hull-repository.worktribe.com/output/518558}, volume = {91}, keyword = {Hull Molecular Imaging Centre, Lab on a Chip, Health and Health Inequalities, Electrochemical cell, Fluorine-18, Separation, Positron emission tomography, FDG, Radiochemical synthesis}, year = {2014}, author = {He, Ping and Haswell, Stephen J. and Pamme, Nicole and Archibald, Stephen J.} }