@article { , title = {A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia}, abstract = {Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10-9), 4q26 (rs6858698, P = 3.07 × 10-9), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10-10) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10-8). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10-7) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10-10) and 8q22.3 (rs2511714, P = 2.90 × 10-9). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL. © 2014 Nature America, Inc.}, doi = {10.1038/ng.2843}, eissn = {1546-1718}, issn = {1061-4036}, issue = {1}, journal = {Nature Genetics}, pages = {56-60}, publicationstatus = {Published}, publisher = {Nature Publishing Group}, url = {https://hull-repository.worktribe.com/output/752336}, volume = {46}, keyword = {Health and Health Inequalities, Genetics}, year = {2014}, author = {Sava, Georgina P. and Sunter, Nicola J. and Smedby, Karin E. and Hall, Andrew G. and Jackson, Graham H. and Allan, James M. and Speedy, Helen E. and Di Bernardo, Maria Chiara and Sava, Georgina P and Dyer, Martin J S and Holroyd, Amy and Wang, Yufei and Sunter, Nicola J and Mansouri, Larry and Juliusson, Gunnar and Smedby, Karin E and Roos, Göran and Jayne, Sandrine and Majid, Aneela and Dearden, Claire and Hall, Andrew G and Mainou-Fowler, Tryfonia and Jackson, Graham H and Summerfield, Geoffrey and Harris, Robert J. and Pettitt, Andrew R. and Allsup, David J. and Bailey, James R. and Pratt, Guy and Pepper, Chris and Fegan, Chris and Rosenquist, Richard and Catovsky, Daniel and Allan, James M and Houlston, Richard S} }