2026-09-20T16:41:27Z hull-repository.worktribe.com

oai:hull-repository.worktribe.com:4208901 2026-06-12T14:07:09Z 084104101115105115 openaccess

Thesis The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known. Xiao, Yu Pei PhD Doctoral 2008-04-01 Compton, Steven J. Morice, Alyn H. University of Hull oai:hull-repository.worktribe.com:4208901 https://hull-repository.worktribe.com/4208901/1/Thesis University of Hull Medicine https://hull-repository.worktribe.com/output/4208901 2008 en openAccess Public