Outputs (82)

Spill-in counts in the quantification of 18F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region (2019)
Journal Article
López-González, F. J., Moscoso, A., Efthimiou, N., Fernández-Ferreiro, A., Piñeiro-Fiel, M., Archibald, S. J., …Silva-Rodríguez, J. (2019). Spill-in counts in the quantification of 18F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region. EJNMMI Physics, 6, Article 27. https://doi.org/10.1186/s40658-019-0258-7

© 2019, The Author(s). Background: We aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM in... Read More about Spill-in counts in the quantification of 18F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region.

Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets (2019)
Journal Article
Antwi-Baffour, S., Malibha-Pinchbeck, M., Stratton, D., Jorfi, S., Lange, S., & Inal, J. (2020). Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets. Journal of Extracellular Vesicles, 9(1), Article 1697124. https://doi.org/10.1080/20013078.2019.1697124

This study sought to measure medium-sized extracellular vesicles (mEVs) in plasma, when patients have low Plasmodium falciparum early in infection. We aimed to define the relationship between plasma mEVs and: (i) parasitaemia, (ii) period from onset... Read More about Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets.

Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale (2019)
Journal Article
Jones, H., Papageorgiou, M., Gordon, A., Ehtesham, Javed, Z., Wells, L. K., …Sathyapalan, T. (2020). Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale. Biochemical Pharmacology, 173, Article 113754. https://doi.org/10.1016/j.bcp.2019.113754

© 2019 Elsevier Inc. This study describes the screening of 13 commercially-available plant extracts for pharmacological activity modulating vascular function using an endothelial cell model. A French maritime pine bark extract (FMPBE) was found to ha... Read More about Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale.

Biochemical and immunocytochemical characterization of coronins in platelets (2019)
Journal Article
Riley, D. R., Khalil, J. S., Naseem, K. M., & Rivero, F. (in press). Biochemical and immunocytochemical characterization of coronins in platelets. Platelets, 1-12. https://doi.org/10.1080/09537104.2019.1696457

Results Platelets express at least four coronins Proteomics and transcriptomics studies indicate that both human and mouse platelets express Coro1, 2, 3 and 7, while other coronins are practically undetectable (Supplemental Table 1 and 2). To demonst... Read More about Biochemical and immunocytochemical characterization of coronins in platelets.

Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow (2019)
Journal Article
Algarni, A., Greenman, J., & Madden, L. A. (2019). Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow. Biomicrofluidics, 13(6), Article 064124. https://doi.org/10.1063/1.5123462

Tumor patients are at a high risk of venous thromboembolism (VTE), and the mechanism by which this occurs may involve tumor-derived microvesicles (MVs). Previously, it has been shown that tumor MVs become attached to endothelial cells in static condi... Read More about Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow.

Isolated tumour microparticles induce endothelial microparticle release in vitro (2019)
Journal Article
Faulkner, L. G., Alqarni, S., Maraveyas, A., & Madden, L. A. (2020). Isolated tumour microparticles induce endothelial microparticle release in vitro. Blood Coagulation and Fibrinolysis, 31(1), 35-42. https://doi.org/10.1097/MBC.0000000000000876

© 2019 Wolters Kluwer Health, Inc. All rights reserved. Cancer induces a hypercoagulable state, resulting in an increased risk of venous thromboembolism. One of the mechanisms driving this is tissue factor (TF) production by the tumour, released in s... Read More about Isolated tumour microparticles induce endothelial microparticle release in vitro.

Analysis of omeprazole and esomeprazole obtained from traditional pharmacies and unlicensed internet websites using Raman spectroscopy, 1H-NMR and chemometric analysis (2019)
Journal Article
Bellia, G. F., Gil-Ramirez, G., Baron, M. G., Croxton, R., & Gonzalez-Rodriguez, J. (2020). Analysis of omeprazole and esomeprazole obtained from traditional pharmacies and unlicensed internet websites using Raman spectroscopy, 1H-NMR and chemometric analysis. Vibrational Spectroscopy, 106, Article 102996. https://doi.org/10.1016/j.vibspec.2019.102996

The relevant therapeutic outcomes obtained with the use of proton pump inhibitors for the treatment of gastric conditions have an important reflection on the prescribing habits of clinicians of primary and secondary care organizations. With the attem... Read More about Analysis of omeprazole and esomeprazole obtained from traditional pharmacies and unlicensed internet websites using Raman spectroscopy, 1H-NMR and chemometric analysis.

Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints (2019)
Journal Article
Das, A. A., Remaud, P., Medlock, J., Das, A. A. K., Allsup, D. J., Madden, L. A., …Paunov, V. N. (2019). Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints. Materials Chemistry Frontiers, 4(1), 197-205. https://doi.org/10.1039/c9qm00531e

We report a new approach for separation of blood cancer cells from healthy white blood cells based on cell recognition by surface functionalised particle imprints. We prepared polymeric particle imprints from a layer of suspension of monodisperse PMM... Read More about Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints.

Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy) (2019)
Journal Article
Sadofsky, L. R., Hayman, Y. A., Vance, J., Cervantes, J. L., Fraser, S. D., Wilkinson, H. N., …Morice, A. H. (2019). Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy). Lung, 197(6), 687-698. https://doi.org/10.1007/s00408-019-00288-3

Purpose: There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In thi... Read More about Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy).

Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme (2019)
Journal Article
Vince, R. V., Kirk, R. J., Aye, M. M., Atkin, S. L., & Madden, L. A. (2020). Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme. Cell Stress and Chaperones, 25(1), 73-80. https://doi.org/10.1007/s12192-019-01048-1

Induction of heat shock protein expression and the heat shock (stress) response are seen in exercise. This exercise-induced response is thought protective against cellular stress through the expression of heat shock proteins. The highly inducible hea... Read More about Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme.