Projects (122)

In vitro analysis of thyroid cancer and it's response to radiotherapy May 22, 2015 - May 21, 2018

Development Of A Multimodal Bioimaging Platform For Detecting The Switch To Aggressive Prostate Cancer Oct 1, 2015 - Dec 31, 2018

Platelet cAMP signalling controls thrombosis through enhanced embolisation Oct 1, 2015 - Sep 30, 2018
The activation of protein kinase A (PKA) by prostacyclin inhibits platelet activation and therefore modulates arterial thrombosis. However, the role of PKA in controlling the stability of pre-existing thrombi is unclear. The stability of thrombi is r... Read More about Platelet cAMP signalling controls thrombosis through enhanced embolisation.

Coronin is a negative regulator of platelet spreading and thrombus formation Jul 1, 2016 - Jun 30, 2019
Platelets are a group of blood cells that become sticky and clump together to form Need guidance? blood clots, ensuring that we stop bleeding after injury. However, in some people platelets also form blood clots inside the blood vessels, which may le... Read More about Coronin is a negative regulator of platelet spreading and thrombus formation.

Cardiogoniometry Studies Apr 1, 2016 - Dec 31, 2017

Differentiating the malignant potential of pancreatic cysts Oct 1, 2017 - Dec 31, 2022
The effective diagnosis of pancreatic cancer is often quite challenging, due to a lack of disease-specific symptoms, resulting in the majority of patients presenting with advanced disease, with an associated dismal prognosis. Earlier detection of pan... Read More about Differentiating the malignant potential of pancreatic cysts.

Medical Imaging Alliance: Siberia and Hull Sep 3, 2018 - Sep 2, 2019
British Council Newton Trust monies for a workshop in Novosibirsk on the topic of medical imaging. Aim is to forge good links with universities there and then apply for larger funds.

Bridging grant for Research PhD student Nov 1, 2017 - Apr 18, 2018
The fund is to support the stipend and some of the fees incurred to bridge the funding for the PhD student.

Embryo quality revisited: understanding and reversing the hidden impact of obesity Jun 1, 2019 - Mar 1, 2023

Development and application of a new technology for the targeted management of biofilms in human chronic wounds Nov 1, 2018 - Oct 31, 2019

Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases. Jul 2, 2018 - Aug 28, 2018
Endothelial cells play important roles within the human body. They line blood and lymphatic vessels and regulate the work of cardiovascular and lymphatic systems. The faulty function of endothelial cells often contributes to the development of life-t... Read More about Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases..

Which is the role of arginine methylation of cardiac troponin I in cardiovascular disease? Jan 1, 2019 - Dec 31, 2019
I propose to investigate the relevance of arginine methylation of cardiac troponin I (ArgMe-cTnI), which is a novel cTnI post-translational modification reported here for the first time, in aetiology and diagnosis of cardiac disease. My hypothesis is... Read More about Which is the role of arginine methylation of cardiac troponin I in cardiovascular disease?.

Investigation of immunological response to chemoradiation, using checkpoint inhibitors, in rectal tumours Jan 1, 2019 - Dec 31, 2024
The plan is for Hull to partner with a colleague in Glasgow (Dr Campbell Roxborough) and to pool resources. Both are aiming to recruit 40 patients with locally-advanced, non-metastatic rectal cancer who are deemed suitable by an authorised colorectal... Read More about Investigation of immunological response to chemoradiation, using checkpoint inhibitors, in rectal tumours.

α-synuclein is a key novel regulator of platelet function. Jan 1, 2020 - Dec 31, 2022
Non-Clinical PhD Studentship

Understanding cardiac failure in patients with chronic kidney disease Aug 1, 2018 - Jan 31, 2019
As previously shown Chronic Kidney Disease (CKD) patients have additional cardiovascular risk associated with increased mortality. Uraemic Cardiomyopathy (UCM) a frequent finding in CKD contributes to the poor clinical outcomes. Prof Bhandair and col... Read More about Understanding cardiac failure in patients with chronic kidney disease.

STATIC: A Randomised Phase III Trial Comparing Continuous with Intermittent Treatment Strategies in Chronic Lymphocytic Leukaemia (CLL) Jan 1, 2021 - Mar 31, 2031
Chronic lymphocytic leukaemia (CLL) is a cancer that affects the blood and bone marrow. It tends to progress slowly, and is incurable. CLL is the most common leukaemia in adults. The first treatment for CLL is chemotherapy. This is usually given for... Read More about STATIC: A Randomised Phase III Trial Comparing Continuous with Intermittent Treatment Strategies in Chronic Lymphocytic Leukaemia (CLL).

Evaluating EV as a therapeutic target in Graves’ disease Feb 1, 2019 - Dec 31, 2020
Evaluating EV as a therapeutic target in Graves’ disease

Graves’ disease is an autoimmune disease characterised by elevated circulating autoantibodies to the thyrotropin receptor (TRAB), resulting in hyperthyroidism. Inflammation, char... Read More about Evaluating EV as a therapeutic target in Graves’ disease.

Is zinc a critical modulator of cyclic nucleotide signalling? Oct 1, 2019 - Dec 31, 2022
inc (Zn2+) deficiency is present in multiple conditions from obesity to cancer. However importantly Zn2+ deficiency can lead to a bleeding phenotype.In this proposal we investigate how Zn2+ is important for the control of platelet cyclic nucleotide... Read More about Is zinc a critical modulator of cyclic nucleotide signalling?.

Development of an immune-responsive 3D skin model May 1, 2019 - Jul 31, 2019
The immune system is an essential regulator of normal physiologic and wound repair processes within the skin, and it contributes to the progression of many different skin diseases. The nature of the interactions between circulating immune cells and r... Read More about Development of an immune-responsive 3D skin model.

Utilising tissue-on-a-chip technology as an ex vivo model of breast cancer metastatic colonisation Jul 1, 2019 - Mar 31, 2021
Breast cancer kills over 11,000 women each year in the UK. Virtually all of these women die because their breast cancer cells travel to other organs within the body such as the liver, lungs, bones and brain, where they grow into new tumours and stop... Read More about Utilising tissue-on-a-chip technology as an ex vivo model of breast cancer metastatic colonisation.