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Association between platelet distribution width with serum uric acid in Chinese population

Liu, Xiaoxia; Wang, Huiying; Huang, Chao; Meng, Zhaowei; Zhang, Wenjuan; Li, Yongle; Yu, Xuefang; Du, Xin; Liu, Ming; Sun, Jinhong; Zhang, Qing; Gao, Ying; Song, Kun; Wang, Xing; Zhao, Li; Fan, Yaguang

Authors

Xiaoxia Liu

Huiying Wang

Zhaowei Meng

Wenjuan Zhang

Yongle Li

Xuefang Yu

Xin Du

Ming Liu

Jinhong Sun

Qing Zhang

Ying Gao

Kun Song

Xing Wang

Li Zhao

Yaguang Fan



Abstract

Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. This cross‐sectional study recruited 61,091 ostensible healthy participants (29,259 males and 31,832 females) after implementing exclusion criteria. Clinical data of the enrolled population included anthropometric measurements and serum parameters. Database was sorted by gender, and the association between PDW and hyperuricemia was analyzed after dividing PDW into quartiles. Crude and adjusted odds ratios of PDW for hyperuricemia with 95% confidence intervals were analyzed using binary logistic regression models. We found no significant difference in PDW values between the genders. Males showed significantly higher incidence of hyperuricemia than females. From binary logistic regression models, significant hyperuricemia risks only were demonstrated in PDW quartiles 2 and 3 in males (P less than 0.05). This study displayed close association between PDW and hyperuricemia as a risk factor. It is meaningful to use PDW as a clinical risk predictor for hyperuricemia in males.

Journal Article Type Article
Publication Date Jan 30, 2019
Print ISSN 0951-6433
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 45
Issue 3
Pages 326-334
APA6 Citation Liu, X., Wang, H., Huang, C., Meng, Z., Zhang, W., Li, Y., …Fan, Y. (2019). Association between platelet distribution width with serum uric acid in Chinese population. BioFactors, 45(3), 326-334. https://doi.org/10.1002/biof.1491
DOI https://doi.org/10.1002/biof.1491
Keywords Platelet distribution width (PDW); Hyperuricemia; Uric acid (UA); Platelets (PLT); Gender
Publisher URL https://iubmb.onlinelibrary.wiley.com/journal/18728081
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