University of Hull logo

Boosting and decreasing action prediction abilities through excitatory and inhibitory tDCS of inferior frontal cortex

Avenanti, Alessio; Paracampo, Riccardo; Annella, Laura; Tidoni, Emmanuele; Aglioti, Salvatore Maria

Authors

Alessio Avenanti

Riccardo Paracampo

Laura Annella

Salvatore Maria Aglioti

Abstract

Influential theories suggest that humans predict others’ upcoming actions by using their own motor system as an internal forward model. However, evidence that the motor system is causally essential for predicting others’ actions is meager. Using transcranial direct current stimulation (tDCS), we tested the role of the inferior frontal cortex (IFC), in action prediction (AP). We devised a novel AP task where participants observed the initial phases of right-hand reaching-to-grasp actions and had to predict their outcome (i.e., the goal/object to be grasped). We found that suppression by cathodal (inhibitory) tDCS of the left IFC, but not the left superior temporal sulcus or the right IFC, selectively impaired performance on the AP task, but not on a difficulty-matched control task. Remarkably, anodal (excitatory) tDCS of the left IFC brought about a selective improvement in the AP task. These findings indicate that the left IFC is necessary for predicting the outcomes of observed human right-hand actions. Crucially, our study shows for the first time that down- and up-regulating excitability within the motor system can hinder and enhance AP abilities, respectively. These findings support predictive coding theories of action perception and have implications for enhancement of AP abilities.

Journal Article Type Article
Publication Date Apr 1, 2018
Journal Cerebral Cortex
Print ISSN 1047-3211
Electronic ISSN 1460-2199
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 28
Issue 4
Pages 1282-1296
Institution Citation Avenanti, A., Paracampo, R., Annella, L., Tidoni, E., & Aglioti, S. M. (2018). Boosting and decreasing action prediction abilities through excitatory and inhibitory tDCS of inferior frontal cortex. Cerebral Cortex, 28(4), 1282-1296. https://doi.org/10.1093/cercor/bhx041
DOI https://doi.org/10.1093/cercor/bhx041
Keywords Action prediction; Inferior frontal cortex; Transcranial direct current stimulation; Action observation network; Neuroenhancement
Publisher URL https://academic.oup.com/cercor/article/28/4/1282/3052754