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Lipids and insulin regulate mitochondrial‐derived peptide ( MOTS ‐c) in PCOS and healthy subjects

Ramanjaneya, Manjunath; Jerobin, Jayakumar; Bettahi, Ilham; Bensila, Milin; Aye, Myint; Siveen, Kodappully Sivaraman; Sathyapalan, Thozhukat; Skarulis, Monica; Abou‐Samra, Abdul‐Badi; Atkin, Stephen Lawrence


Manjunath Ramanjaneya

Stephen Lawrence Atkin

Jayakumar Jerobin

Ilham Bettahi

Milin Bensila

Myint Aye

Kodappully Sivaraman Siveen

Thozhukat Sathyapalan

Monica Skarulis

Abdul‐Badi Abou‐Samra


Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS‐c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activating AKT and AMPK dependent pathways. The current study was designed to examine the response of MOTS‐c to lipids (intralipid) followed by insulin in PCOS and healthy subjects.

All subjects underwent 5‐hour intralipid/saline infusion with a hyperinsulinemic euglycaemic clamp in the final 2 hours. Plasma samples were collected to measure circulating MOTS‐c using a commercial elisa kit. Subsequently this was repeated following an eight week exercise intervention.

Intralipid significantly increased plasma MOTS‐c both in controls and PCOS subjects, whilst the insulin infusion blunted the intralipid induced response seen for both lipids and MOT‐c.

Intralipid elevated plasma MOTS‐c to 232±124% of basal in control (P

Journal Article Type Article
Publication Date May 1, 2019
Journal Clinical Endocrinology
Print ISSN 0300-0664
Electronic ISSN 1365-2265
Publisher Wiley
Peer Reviewed Peer Reviewed
Keywords Endocrinology, Diabetes and Metabolism
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