Curcumin: a modulator of inflammatory signaling pathways in the immune system

Kahkhaie, Kolsoum Rezaie; Mirhosseini, Ali; Aliabadi, Ali; Mohammadi, Asadollah; Mousavi, Mohammad Javad; Haftcheshmeh, Saeed Mohammadian; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1.

Citation

Kahkhaie, K. R., Mirhosseini, A., Aliabadi, A., Mohammadi, A., Mousavi, M. J., Haftcheshmeh, S. M., Sathyapalan, T., & Sahebkar, A. (2019). Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology, 27(5), 885-900. https://doi.org/10.1007/s10787-019-00607-3

• Journal Article Type: Article
• Acceptance Date: May 20, 2019
• Online Publication Date: May 28, 2019
• Publication Date: Oct 1, 2019
• Deposit Date: May 30, 2019
• Publicly Available Date: May 29, 2020
• Journal: Inflammopharmacology
• Print ISSN: 0925-4692
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 27
• Issue: 5
• Pages: 885-900
• DOI: https://doi.org/10.1007/s10787-019-00607-3
• Keywords: Curcumin; Inflammation; Inflammatory signaling pathway; Inflammatory diseases
• Public URL: https://hull-repository.worktribe.com/output/1870421
• Additional Information: Received: 20 February 2019; Accepted: 20 May 2019; First Online: 28 May 2019; : ; : The authors declare that they have no conflict of interest in this study.; : This article does not contain any studies with human participants or animals performed by any of the authors.
• Contract Date: May 30, 2019