Kolsoum Rezaie Kahkhaie
Curcumin: a modulator of inflammatory signaling pathways in the immune system
Kahkhaie, Kolsoum Rezaie; Mirhosseini, Ali; Aliabadi, Ali; Mohammadi, Asadollah; mosavi, Mohammad Javad; Haftcheshmeh, Saeed Mohammadian; Sathyapalan, Thozhukat; Sahebkar, Amirhossein
Mohammad Javad mosavi
Saeed Mohammadian Haftcheshmeh
Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1.
|Journal Article Type||Article|
|Publication Date||May 29, 2019|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Kahkhaie, K. R., Mirhosseini, A., Aliabadi, A., Mohammadi, A., mosavi, M. J., Haftcheshmeh, S. M., …Sahebkar, A. (2019). Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology, https://doi.org/10.1007/s10787-019-00607-3|
|Keywords||Immunology; Pharmacology (medical); Pharmacology|
|Additional Information||Received: 20 February 2019; Accepted: 20 May 2019; First Online: 28 May 2019; : ; : The authors declare that they have no conflict of interest in this study.; : This article does not contain any studies with human participants or animals performed by any of the authors.|
This is a post-peer-review, pre-copyedit version of an article published in Inflammopharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10787-019-00607-3
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