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Curcumin: a modulator of inflammatory signaling pathways in the immune system

Kahkhaie, Kolsoum Rezaie; Mirhosseini, Ali; Aliabadi, Ali; Mohammadi, Asadollah; mosavi, Mohammad Javad; Haftcheshmeh, Saeed Mohammadian; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Kolsoum Rezaie Kahkhaie

Ali Mirhosseini

Ali Aliabadi

Asadollah Mohammadi

Mohammad Javad mosavi

Saeed Mohammadian Haftcheshmeh

Thozhukat Sathyapalan

Amirhossein Sahebkar

Abstract

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1.

Journal Article Type Article
Publication Date May 29, 2019
Journal Inflammopharmacology
Print ISSN 0925-4692
Electronic ISSN 1568-5608
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1007/s10787-019-00607-3
Keywords Immunology; Pharmacology (medical); Pharmacology
Additional Information Received: 20 February 2019; Accepted: 20 May 2019; First Online: 28 May 2019; : ; : The authors declare that they have no conflict of interest in this study.; : This article does not contain any studies with human participants or animals performed by any of the authors.

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