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Journal Article
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences
Abstract
Objectives
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene‐latitude effects.
METHODS
Eighty subjects were examined for VDR gene‐CpG island methylation density. VDR gene variants were also examined by PCR‐RFLP.
CONCLUSIONS
Duration of early‐life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.
Citation
Beckett, E., Jones, P., Veysey, M., Duesing, K., Martin, C., Furst, J., …Lucock, M. (2017). VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences. American Journal of Human Biology, 29(5), Article e23010. https://doi.org/10.1002/ajhb.23010
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 1, 2017 |
Online Publication Date | Apr 22, 2017 |
Publication Date | Sep 8, 2017 |
Deposit Date | Aug 13, 2019 |
Print ISSN | 1520-6300 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 29 |
Issue | 5 |
Article Number | e23010 |
DOI | https://doi.org/10.1002/ajhb.23010 |
Public URL | https://hull-repository.worktribe.com/output/1932503 |
Publisher URL | https://onlinelibrary.wiley.com/doi/full/10.1002/ajhb.23010 |
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