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Low temperature plasma: a novel focal therapy for localized prostate cancer?

Hirst, Adam M.; Frame, Fiona M.; Maitland, Norman J.; O’Connell, Deborah

Authors

Adam M. Hirst

Fiona M. Frame

Norman J. Maitland

Deborah O’Connell



Abstract

Despite considerable advances in recent years for the focal treatment of localized prostate cancer, high recurrence rates and detrimental side effects are still a cause for concern. In this review, we compare current focal therapies to a potentially novel approach for the treatment of early onset prostate cancer: low temperature plasma. The rapidly evolving plasma technology has the potential to deliver a wide range of promising medical applications via the delivery of plasma-induced reactive oxygen and nitrogen species. Studies assessing the effect of low temperature plasma on cell lines and xenografts have demonstrated DNA damage leading to apoptosis and reduction in cell viability. However, there have been no studies on prostate cancer, which is an obvious candidate for this novel therapy. We present here the potential of low temperature plasma as a focal therapy for prostate cancer.

Citation

Hirst, A. M., Frame, F. M., Maitland, N. J., & O’Connell, D. (2014). Low temperature plasma: a novel focal therapy for localized prostate cancer?. Biomed research international, 2014, Article 878319. https://doi.org/10.1155/2014/878319

Journal Article Type Article
Acceptance Date Feb 6, 2014
Online Publication Date Mar 13, 2014
Publication Date 2014
Deposit Date Jun 25, 2019
Publicly Available Date Jun 25, 2019
Journal BioMed Research International
Print ISSN 2314-6133
Publisher Hindawi
Peer Reviewed Peer Reviewed
Volume 2014
Article Number 878319
DOI https://doi.org/10.1155/2014/878319
Public URL https://hull-repository.worktribe.com/output/2037340
Publisher URL https://www.hindawi.com/journals/bmri/2014/878319/
Additional Information Copyright © 2014 Adam M. Hirst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Contract Date Jun 25, 2019

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Publisher Licence URL
http://creativecommons.org/licenses/by/3.0

Copyright Statement
Copyright © 2014 Adam M. Hirst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.






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