Low temperature plasma: a novel focal therapy for localized prostate cancer?

Hirst, Adam M.; Frame, Fiona M.; Maitland, Norman J.; O’Connell, Deborah

Abstract

Despite considerable advances in recent years for the focal treatment of localized prostate cancer, high recurrence rates and detrimental side effects are still a cause for concern. In this review, we compare current focal therapies to a potentially novel approach for the treatment of early onset prostate cancer: low temperature plasma. The rapidly evolving plasma technology has the potential to deliver a wide range of promising medical applications via the delivery of plasma-induced reactive oxygen and nitrogen species. Studies assessing the effect of low temperature plasma on cell lines and xenografts have demonstrated DNA damage leading to apoptosis and reduction in cell viability. However, there have been no studies on prostate cancer, which is an obvious candidate for this novel therapy. We present here the potential of low temperature plasma as a focal therapy for prostate cancer.

Citation

Hirst, A. M., Frame, F. M., Maitland, N. J., & O’Connell, D. (2014). Low temperature plasma: a novel focal therapy for localized prostate cancer?. Biomed research international, 2014, Article 878319. https://doi.org/10.1155/2014/878319

• Journal Article Type: Article
• Acceptance Date: Feb 6, 2014
• Online Publication Date: Mar 13, 2014
• Publication Date: 2014
• Deposit Date: Jun 25, 2019
• Publicly Available Date: Jun 25, 2019
• Journal: BioMed Research International
• Print ISSN: 2314-6133
• Electronic ISSN: 2314-6141
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2014
• Article Number: 878319
• DOI: https://doi.org/10.1155/2014/878319
• Public URL: https://hull-repository.worktribe.com/output/2037340
• Publisher URL: https://www.hindawi.com/journals/bmri/2014/878319/
• Additional Information: Copyright © 2014 Adam M. Hirst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.