University of Hull logo

Low temperature plasma: a novel focal therapy for localized prostate cancer?

Hirst, Adam M.; Frame, Fiona M.; Maitland, Norman J.; O’Connell, Deborah

Authors

Adam M. Hirst

Norman J. Maitland

Deborah O’Connell

Abstract

Despite considerable advances in recent years for the focal treatment of localized prostate cancer, high recurrence rates and detrimental side effects are still a cause for concern. In this review, we compare current focal therapies to a potentially novel approach for the treatment of early onset prostate cancer: low temperature plasma. The rapidly evolving plasma technology has the potential to deliver a wide range of promising medical applications via the delivery of plasma-induced reactive oxygen and nitrogen species. Studies assessing the effect of low temperature plasma on cell lines and xenografts have demonstrated DNA damage leading to apoptosis and reduction in cell viability. However, there have been no studies on prostate cancer, which is an obvious candidate for this novel therapy. We present here the potential of low temperature plasma as a focal therapy for prostate cancer.

Journal Article Type Article
Publication Date 2014
Journal BioMed Research International
Print ISSN 2314-6133
Electronic ISSN 2314-6141
Publisher Hindawi
Peer Reviewed Peer Reviewed
Volume 2014
Article Number 878319
Institution Citation Hirst, A. M., Frame, F. M., Maitland, N. J., & O’Connell, D. (2014). Low temperature plasma: a novel focal therapy for localized prostate cancer?. Biomed research international, 2014, https://doi.org/10.1155/2014/878319
DOI https://doi.org/10.1155/2014/878319
Publisher URL https://www.hindawi.com/journals/bmri/2014/878319/
Additional Information Copyright © 2014 Adam M. Hirst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Files

Article (2.8 Mb)
PDF

Copyright Statement
Copyright © 2014 Adam M. Hirst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.




You might also like


Downloadable Citations