University of Hull logo

MRI and PET/MRI in hematologic malignancies: MRI and PET/MRI in Hematologic Malignancies

Mayerhoefer, Marius E.; Archibald, Stephen J.; Messiou, Christina; Staudenherz, Anton; Berzaczy, Dominik; Schöder, Heiko

Authors

Marius E. Mayerhoefer

Christina Messiou

Anton Staudenherz

Dominik Berzaczy

Heiko Schöder

Abstract

The role of MRI differs considerably between the three main groups of hematological malignancies: lymphoma, leukemia,
and myeloma. In myeloma, whole-body MRI (WB-MRI) is recognized as a highly sensitive test for the assessment of myeloma,
and is also endorsed by clinical guidelines, especially for detection and staging. In lymphoma, WB-MRI is presently
not recommended, and merely serves as an alternative technique to the current standard imaging test, [18F]FDG-PET/CT,
especially in pediatric patients. Even for lymphomas with variable FDG avidity, such as extranodal mucosa-associated lymphoid
tissue lymphoma (MALT), contrast-enhanced computed tomography (CT), but not WB-MRI, is presently recommended,
despite the high sensitivity of diffusion-weighted MRI and its ability to capture treatment response that has
been reported in the literature. In leukemia, neither MRI nor any other cross-sectional imaging test (including positron
emission tomography [PET]) is currently recommended outside of clinical trials. This review article discusses current clinical
applications as well as the main research topics for MRI, as well as PET/MRI, in the field of hematological malignancies,
with a focus on functional MRI techniques such as diffusion-weighted imaging and dynamic contrast-enhanced MRI, on the
one hand, and novel, non-FDG PET imaging probes such as the CXCR4 radiotracer [68Ga]Ga-Pentixafor and the amino acid
radiotracer [11C]methionine, on the other hand.

Journal Article Type Article
Publication Date Jul 1, 2019
Journal Journal of Magnetic Resonance Imaging
Print ISSN 1053-1807
Publisher Wiley
Peer Reviewed Peer Reviewed
Institution Citation Mayerhoefer, M. E., Archibald, S. J., Messiou, C., Staudenherz, A., Berzaczy, D., & Schöder, H. (2019). MRI and PET/MRI in hematologic malignancies: MRI and PET/MRI in Hematologic Malignancies. Journal of magnetic resonance imaging : JMRI, https://doi.org/10.1002/jmri.26848
DOI https://doi.org/10.1002/jmri.26848
Keywords Radiology Nuclear Medicine and imaging
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1002/jmri.26848

Files

Article (5.1 Mb)
PDF

Copyright Statement
© 2019 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.




You might also like


Downloadable Citations