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Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet

Ganie, Mohd Ashraf; Sahar, Tajali; Rashid, Aafia; Wani, Ishfaq A.; Nisar, Sobia; Sathyapalan, Thozhukat; Vishnubhatla, Sreenivas; Ramakrishnan, Lakshmy; Parvez, Tabasum; Geer, Ishaq

Authors

Mohd Ashraf Ganie

Tajali Sahar

Aafia Rashid

Ishfaq A. Wani

Sobia Nisar

Thozhukat Sathyapalan

Sreenivas Vishnubhatla

Lakshmy Ramakrishnan

Tabasum Parvez

Ishaq Geer



Abstract

Background: Sub-inflammation and insulin resistance characterize women with PCOS. Data on dietary modulation of inflammation among PCOS women is scant, particularly from Indian subcontinent. The present study aimed to assess the effect of plant based vs. animal origin diets on serum markers of inflammation (primary outcome measure).

Methods: This observational case-control study compared age and BMI matched PCOS and apparently healthy women from two populations following different dietary practices. The vegetarian women from New-Delhi (n = 82 PCOS and n = 179 healthy) and non-vegetarian women from Srinagar (n = 62 PCOS and n = 141 healthy) formed the groups. Using a uniform methodology, detailed clinical, biochemical, hormonal, and inflammatory marker assessment was undertaken.

Results: The mean age of the overall cohort was 26.23 ± 4.59 years with a mean BMI of 24.39 ± 3.72 kg/m2. Overall pro-inflammatory markers (TNF-α, IL-6, IL-1β, hs-CRP and serum resistin) were significantly higher (p ≤ 0.05) and anti-inflammatory markers (IL-10 and adiponectin) were lower among women with PCOS than healthy subjects. On comparing vegetarian women with non-vegetarians, higher daily calorie intake (1895.46 ± 258.19 vs. 1860.13 ± 323.96 Kcal) with a higher protein and fat and lower carbohydrate intake was recorded in the latter, although the percent energy derived from carbohydrates was higher among vegetarians. Clinical and biochemical parameters were comparable among the groups except mFG score, total serum testosterone and serum lipid levels which were higher among non-vegetarian women as compared to their vegetarian counterparts from both categories (PCOS and healthy). Interestingly, vegetarian women with PCOS and healthy women had higher serum pro-inflammatory and lower anti-inflammatory markers compared to their non-vegetarian counterparts.

Conclusion: Women with PCOS consuming Indian vegetarian diet have higher pro-inflammatory and lower anti-inflammatory marker levels than their age and BMI matched healthy non-vegetarian counterparts. This interesting observation can be attributed to the dietary composition, among other factors and needs confirmation from well-designed randomized studies on a larger cohort.

Citation

Sathyapalan, T., Ganie, M. A., Nisar, S., Sahar, T., Parvez, T., Rashid, A., …Vishnubhatla, S. (2019). Comparative Evaluation of Biomarkers of Inflammation Among Indian Women With Polycystic Ovary Syndrome (PCOS) Consuming Vegetarian vs. Non-vegetarian Diet. Frontiers in endocrinology, 10, https://doi.org/10.3389/fendo.2019.00699

Journal Article Type Article
Acceptance Date Nov 18, 2019
Online Publication Date Nov 8, 2019
Publication Date Dec 1, 2019
Deposit Date Dec 1, 2019
Publicly Available Date Dec 2, 2019
Journal Frontiers in Endocrinology
Print ISSN 1664-2392
Electronic ISSN 1664-2392
Publisher Frontiers Media
Peer Reviewed Not Peer Reviewed
Volume 10
Article Number 699
DOI https://doi.org/10.3389/fendo.2019.00699
Keywords PCOS; Inflammation; Insulin resistance; Testosterone; hs-CRP; Adiponectin
Public URL https://hull-repository.worktribe.com/output/3276091

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
Copyright © 2019 Ganie, Sahar, Rashid, Wani, Nisar, Sathyapalan, Vishnubhatla, Ramakrishnan, Parvez and Geer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.





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