An investigation of Digoxin by Cyclic Voltammetry using Gold and Silver Solid Electrodes and Chemometric Analysis

Bellia, Gaetano; Corrall, Hannah; Baron, Mark; Croxton, Ruth; Gonzalez-Rodriguez, Jose

doi:10.20964/2017.04.60

An investigation of Digoxin by Cyclic Voltammetry using Gold and Silver Solid Electrodes and Chemometric Analysis

Bellia, Gaetano; Corrall, Hannah; Baron, Mark; Croxton, Ruth; Gonzalez-Rodriguez, Jose

Authors

Gaetano Bellia

Hannah Corrall

Mark Baron

Ruth Croxton

Jose Gonzalez-Rodriguez

Abstract

Digoxin, one of the main cardiac glycosides medication, has shown to have a strong analytical response under investigation by voltammetric analysis using mercury electrodes, achieving nanomole sensitivity. In this study we investigated the suitability of solid electrodes as gold and silver electrodes in voltammetric analysis of this active pharmaceutical ingredient. The scope of the investigation was to evaluate if the use of these solid electrodes, more practical and especially less dangerous, under an operative and environmental aspects could represent a valid further possibility to add to the use of the mercury ones. Both of the solid electrodes have been tested at different pH of 5, 7.4, 10, and 11. PCA analysis has been performed and specific responses achieved. Micromole sensitivity has been achieved for both of the electrodes, showing that the use of these sensors could represent a preliminary analytical approach when the more accurate alternative choice is not necessary, being more practical and less environmental impacting than using mercury.

Citation

Bellia, G., Corrall, H., Baron, M., Croxton, R., & Gonzalez-Rodriguez, J. (2017). An investigation of Digoxin by Cyclic Voltammetry using Gold and Silver Solid Electrodes and Chemometric Analysis. International Journal of Electrochemical Science, 12, 3050-3062. https://doi.org/10.20964/2017.04.60

Journal Article Type	Article
Acceptance Date	Feb 28, 2017
Publication Date	Mar 12, 2017
Deposit Date	Dec 18, 2019
Publicly Available Date	Dec 18, 2019
Journal	International Journal of Electrochemical Science
Publisher	ESG
Peer Reviewed	Peer Reviewed
Volume	12
Pages	3050-3062
DOI	https://doi.org/10.20964/2017.04.60
Keywords	digoxin, voltammetry, solid electrodes, PCA analysis
Public URL	https://hull-repository.worktribe.com/output/3316064