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A dyadic growth modeling approach to examine associations between weight gain and lung function decline: The NHLBI Pooled Cohorts Study

Cornelius, Talea ; Schwartz, Joseph E. ; Balte, Pallavi ; Bhatt, Surya P. ; Cassano, Patricia A. ; Currow, David ; Jacobs, David R. ; Johnson, Miriam ; Kalhan, Ravi ; Kronmal, Richard ; Loehr, Laura ; O’Connor, George T. ; Smith, Benjamin ; White, Wendy B. ; Yende, Sachin ; Oelsner, Elizabeth C.

Authors

Talea Cornelius

Joseph E. Schwartz

Pallavi Balte

Surya P. Bhatt

Patricia A. Cassano

David Currow

David R. Jacobs

Ravi Kalhan

Richard Kronmal

Laura Loehr

George T. O’Connor

Benjamin Smith

Wendy B. White

Sachin Yende

Elizabeth C. Oelsner



Abstract

The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI) and lung function as paired, within-person outcomes, we test the hypothesis that individuals with more rapid increase in BMI exhibit more rapid decline in lung function: forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and their ratio (FEV1/FVC). Models included random intercepts and slopes and were adjusted for socio-demographic and smoking-related factors. A sample of 9,115 adults with paired measurements of BMI and lung function at ≥3 visits were selected from a pooled set of 5 US population-based cohorts (mean age at baseline, 46 years; median follow-up, 19 years). At age 46, average annual rates-of-change in BMI, FEV1, FVC, and FEV1/FVC were 0.22 kg/m2/year, -25.50 mL/year, -21.99 mL/year, and -0.24 percent/year, respectively. Individuals with steeper BMI increases had faster declines in FEV1 (r=-0.16) and FVC (r=-0.26), and slower declines in FEV1/FVC (r=0.11) (all P

Journal Article Type Article
Journal American Journal of Epidemiology
Print ISSN 0002-9262
Electronic ISSN 1476-6256
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Article Number kwaa059
APA6 Citation Cornelius, T., Schwartz, J. E., Balte, P., Bhatt, S. P., Cassano, P. A., Currow, D., …Oelsner, E. C. (in press). A dyadic growth modeling approach to examine associations between weight gain and lung function decline: The NHLBI Pooled Cohorts Study. American Journal of Epidemiology, https://doi.org/10.1093/aje/kwaa059
DOI https://doi.org/10.1093/aje/kwaa059
Keywords (3-8): BMI; Cohort studies; COPD; Dyadic models; Longitudinal; Lung function; Obesity; Spirometry
Publisher URL https://academic.oup.com/aje/advance-article-abstract/doi/10.1093/aje/kwaa059/5819837?redirectedFrom=fulltext
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