A dyadic growth modeling approach to examine associations between weight gain and lung function decline: The NHLBI Pooled Cohorts Study
Cornelius, Talea ; Schwartz, Joseph E. ; Balte, Pallavi ; Bhatt, Surya P. ; Cassano, Patricia A. ; Currow, David ; Jacobs, David R. ; Johnson, Miriam ; Kalhan, Ravi ; Kronmal, Richard ; Loehr, Laura ; O’Connor, George T. ; Smith, Benjamin ; White, Wendy B. ; Yende, Sachin ; Oelsner, Elizabeth C.
Joseph E. Schwartz
Surya P. Bhatt
Patricia A. Cassano
David R. Jacobs
Professor Miriam Johnson Miriam.Johnson@hull.ac.uk
George T. O’Connor
Wendy B. White
Elizabeth C. Oelsner
The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI) and lung function as paired, within-person outcomes, we test the hypothesis that individuals with more rapid increase in BMI exhibit more rapid decline in lung function: forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and their ratio (FEV1/FVC). Models included random intercepts and slopes and were adjusted for socio-demographic and smoking-related factors. A sample of 9,115 adults with paired measurements of BMI and lung function at ≥3 visits were selected from a pooled set of 5 US population-based cohorts (mean age at baseline, 46 years; median follow-up, 19 years). At age 46, average annual rates-of-change in BMI, FEV1, FVC, and FEV1/FVC were 0.22 kg/m2/year, -25.50 mL/year, -21.99 mL/year, and -0.24 percent/year, respectively. Individuals with steeper BMI increases had faster declines in FEV1 (r=-0.16) and FVC (r=-0.26), and slower declines in FEV1/FVC (r=0.11) (all P
|Journal Article Type||Article|
|Journal||American Journal of Epidemiology|
|Publisher||Oxford University Press (OUP)|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Cornelius, T., Schwartz, J. E., Balte, P., Bhatt, S. P., Cassano, P. A., Currow, D., …Oelsner, E. C. (in press). A dyadic growth modeling approach to examine associations between weight gain and lung function decline: The NHLBI Pooled Cohorts Study. American Journal of Epidemiology, https://doi.org/10.1093/aje/kwaa059|
|Keywords||(3-8): BMI; Cohort studies; COPD; Dyadic models; Longitudinal; Lung function; Obesity; Spirometry|
This file is under embargo until Apr 15, 2021 due to copyright reasons.
Contact D.Wood@hull.ac.uk to request a copy for personal use.
You might also like
Low agreement between mMRC rated by patients and clinicians ─ implications for practice
Mental wellbeing in bereaved carers: A Health Survey for England population study