A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline

Cornelius, Talea; Schwartz, Joseph E.; Balte, Pallavi; Bhatt, Surya P.; Cassano, Patricia A.; Currow, David; Jacobs, David R.; Johnson, Miriam; Kalhan, Ravi; Kronmal, Richard; Loehr, Laura; O’Connor, George T.; Smith, Benjamin; White, Wendy B.; Yende, Sachin; Oelsner, Elizabeth C.

Abstract

The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we tested the hypothesis that persons with more rapid increase in BMI exhibit more rapid decline in lung function, as measured by forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio (FEV1:FVC). Models included random intercepts and slopes and adjusted for sociodemographic and smoking-related factors. A sample of 9,115 adults with paired measurements of BMI and lung function taken at ≥3 visits were selected from a pooled set of 5 US population-based cohort studies (1983-2018; mean age at baseline = 46 years; median follow-up, 19 years). At age 46 years, average annual rates of change in BMI, FEV1, FVC, and FEV1:FVC ratio were 0.22 kg/m2/year, -25.50 mL/year, -21.99 mL/year, and-0.24%/year, respectively. Persons with steeper BMI increases had faster declines in FEV1 (r=-0.16) and FVC (r=-0.26) and slower declines in FEV1:FVC ratio (r=0.11) (all Pvalues

Citation

Cornelius, T., Schwartz, J. E., Balte, P., Bhatt, S. P., Cassano, P. A., Currow, D., …Oelsner, E. C. (2020). A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline. American Journal of Epidemiology, 189(10), 1173-1184. https://doi.org/10.1093/aje/kwaa059

• Journal Article Type: Article
• Acceptance Date: Apr 10, 2020
• Online Publication Date: Apr 14, 2020
• Publication Date: Oct 1, 2020
• Deposit Date: Apr 1, 2020
• Publicly Available Date: Apr 15, 2021
• Journal: American journal of epidemiology
• Print ISSN: 0002-9262
• Electronic ISSN: 1476-6256
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 189
• Issue: 10
• Article Number: kwaa059
• Pages: 1173-1184
• DOI: https://doi.org/10.1093/aje/kwaa059
• Keywords: (3-8): BMI; Cohort studies; COPD; Dyadic models; Longitudinal; Lung function; Obesity; Spirometry
• Public URL: https://hull-repository.worktribe.com/output/3486571
• Publisher URL: https://academic.oup.com/aje/advance-article-abstract/doi/10.1093/aje/kwaa059/5819837?redirectedFrom=fulltext