Abu Saleh Md Moin
Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia
Moin, Abu Saleh Md; Al-Qaissi, Ahmed; Sathyapalan, Thozhukat; Atkin, Stephen L.; Butler, Alexandra E.
Authors
Ahmed Al-Qaissi
Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Stephen L. Atkin
Alexandra E. Butler
Abstract
Objective
Hypoglycemia in diabetes (T2D) may increase the risk for Alzheimer's disease (AD). We hypothesized that hypoglycemia‐induced amyloid‐related protein changes would be exacerbated in T2D.
Methods
A prospective, parallel study in T2D (n=23) and controls (n=23). Subjects underwent insulin‐induced hypoglycemia with blood sampling at baseline, hypoglycemia and post‐hypoglycemia; proteomic analysis of amyloid‐related proteins was undertaken.
Results
At baseline: Amyloid‐precursor protein (APP) (p
Citation
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (in press). Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.14220
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 4, 2020 |
Online Publication Date | Oct 7, 2020 |
Deposit Date | Oct 13, 2020 |
Publicly Available Date | Oct 8, 2021 |
Journal | Diabetes, Obesity and Metabolism |
Print ISSN | 1462-8902 |
Electronic ISSN | 1463-1326 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1111/dom.14220 |
Keywords | Type 2 diabetes; Hypoglycemia; Dementia; Alzheimer's disease; Amyloid‐related proteins |
Public URL | https://hull-repository.worktribe.com/output/3633660 |
Publisher URL | https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14220 |
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Copyright Statement
©2020 The authors. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder
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