Michael R. Reithofer
Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy
Reithofer, Michael R.; Chan, Kiat-Hwa; Lakshmanan, Anupama; Lam, Dang Hoang; Mishra, Archana; Gopalan, Began; Joshi, Mangesh; Wang, Shu; Hauser, Charlotte A. E.
Authors
Kiat-Hwa Chan
Anupama Lakshmanan
Dang Hoang Lam
Archana Mishra
Began Gopalan
Mangesh Joshi
Shu Wang
Charlotte A. E. Hauser
Abstract
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.
Citation
Reithofer, M. R., Chan, K., Lakshmanan, A., Lam, D. H., Mishra, A., Gopalan, B., …Hauser, C. A. E. (2014). Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy. Chemical science, 5(2), 625-630. https://doi.org/10.1039/c3sc51930a
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 17, 2013 |
Online Publication Date | Oct 18, 2013 |
Publication Date | Feb 1, 2014 |
Deposit Date | Oct 30, 2015 |
Publicly Available Date | Nov 23, 2017 |
Journal | Chemical science |
Print ISSN | 2041-6520 |
Electronic ISSN | 2041-6539 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 5 |
Issue | 2 |
Pages | 625-630 |
DOI | https://doi.org/10.1039/c3sc51930a |
Keywords | Anti-cancer drugs; Ultrashort peptides; Breast cancer therapy |
Public URL | https://hull-repository.worktribe.com/output/380639 |
Publisher URL | http://pubs.rsc.org/en/Content/ArticleLanding/2014/SC/C3SC51930A#!divAbstract |
Additional Information | Author's accepted manuscript of article published in: Chemical science, 2014, issue 2 |
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Copyright Statement
©2015 University of Hull
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