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Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs

Ashrafizadeh, Milad; Ahmadi, Zahra; Yaribeygi, Habib; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein


Milad Ashrafizadeh

Zahra Ahmadi

Habib Yaribeygi

Tannaz Jamialahmadi

Amirhossein Sahebkar


Amirhossein Sahebkar


MicroRNAs (miRNAs) are endogenous short noncoding RNAs with approximately 22 nucleotides. The primary function of miRNAs is the negative regulation of target gene expression via mRNA degradation or translation inhibition. During recent years, much attention has been made toward miRNAs’ role in different disorders; particularly cancer and compounds with modulatory effects on miRNAs are of interest. Melatonin is one of these compounds which is secreted by the pineal gland. Also, melatonin is present in the leaves, fruits, and seeds of plants. Melatonin has several valuable biological activities such as antioxidant, anti-inflammation, antitumor, and antiaging activities. This important agent is extensively used to treat different disorders such as cancer and neurodegenerative and cardiovascular diseases. This review aims to describe the modulatory effect of melatonin on miRNAs as novel targets.


Ashrafizadeh, M., Ahmadi, Z., Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases (463-471). Cham: Springer.

Online Publication Date Jan 3, 2022
Publication Date Jan 3, 2022
Deposit Date Oct 2, 2022
Publicly Available Date Jan 4, 2024
Publisher Springer
Pages 463-471
Series Title Advances in Experimental Medicine and Biology
Series Number 1328
Series ISSN 0065-2598 ; 2214-8019
Book Title Natural Products and Human Diseases
ISBN 9783030732332
Public URL


Accepted manuscript (398 Kb)

Copyright Statement
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

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