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Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes

Sathyapalan, Thozhukat; Atkin, Stephen L.; Kilpatrick, Eric S.

Authors

Stephen L. Atkin

Eric S. Kilpatrick



Abstract

OBJECTIVE - Reduction in LDL and high sensitivity (hs) C-reactive protein (CRP) are independent indicators of successful cardiovascular risk reduction with statins. This study compared the effect of equivalent LDL-lowering doses of simvastatin and atorvastatin on hsCRP in type 2 diabetic patients. RESEARCH DESIGN AND METHODS - A crossover study of 26 patients with type 2 diabetes taking either 40 mg simvastatin or 10 mg atorvastatin was undertaken. After 3 months on one statin, lipids and hsCRP were measured on 10 occasions over a 5-week period. The same procedure was then followed taking the other statin. RESULTS - LDL was comparable on either treatment: atorvastatin 2.2 +/- 0.2 vs. 2.1 +/- 0.3 mmol/l (mean +/- SD; P = 0.19). CRP of individuals taking atorvastatin was significantly lower than when they were taking simvastatin (median 1.08 vs. 1.47 mg/l, P = 0.0002) and was less variable (median SD of logCRP 0.0036 vs. 0.178, P = 0.0001). CONCLUSIONS - Compared with simvastatin, atorvastatin reduced hsCRP and its variability in type 2 diabetic patients. This enhanced anti-inflammatory effect may prove beneficial if lower CRP is associated with improved cardiovascular risk.

Citation

Sathyapalan, T., Atkin, S. L., & Kilpatrick, E. S. (2010). Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes. Diabetes Care, 33(9), 1948-1950. https://doi.org/10.2337/dc10-0201

Journal Article Type Article
Acceptance Date Jun 11, 2010
Online Publication Date Aug 30, 2010
Publication Date Sep 1, 2010
Publicly Available Date Mar 29, 2024
Journal DIABETES CARE
Print ISSN 0149-5992
Electronic ISSN 1935-5548
Publisher American Diabetes Association
Peer Reviewed Peer Reviewed
Volume 33
Issue 9
Pages 1948-1950
DOI https://doi.org/10.2337/dc10-0201
Keywords Internal Medicine; Endocrinology, Diabetes and Metabolism; Advanced and Specialised Nursing
Public URL https://hull-repository.worktribe.com/output/396333

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