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Going the distance: human population genetics in a clinal world

Lawson Handley, Lori J.; Manica, Andrea; Goudet, Jérôme; Balloux, François


Andrea Manica

Jérôme Goudet

François Balloux


Global human genetic variation is greatly influenced by geography, with genetic differentiation between populations increasing with geographic distance and within-population diversity decreasing with distance from Africa. In fact, these ’clines’ can explain most of the variation in human populations. Despite this, population genetics inferences often rely on models that do not take geography into account, which could result in misleading conclusions when working at global geographic scales. Geographically explicit approaches have great potential for the study of human population genetics. Here, we discuss the most promising avenues of research in the context of human settlement history and the detection of genomic elements under natural selection. We also review recent technical advances and address the challenges of integrating geography and genetics.


Lawson Handley, L. J., Manica, A., Goudet, J., & Balloux, F. (2007). Going the distance: human population genetics in a clinal world. Trends in Genetics, 23(9), 432-439.

Journal Article Type Article
Online Publication Date Jul 25, 2007
Publication Date 2007-09
Journal Trends in Genetics
Print ISSN 0168-9525
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 23
Issue 9
Pages 432-439
Keywords Genetics
Public URL
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