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Uremic cardiomyopathy and insulin resistance: a critical role for Akt?

Semple, David; Smith, Katie; Bhandari, Sunil; Seymour, Anne Marie L.


David Semple

Katie Smith

Sunil Bhandari

Anne Marie L. Seymour


Uremic cardiomyopathy is a classic complication of chronic renal failure whose cause is unclear and treatment remains disappointing. Insulin resistance is an independent predictor of cardiovascular mortality in chronic renal failure. Underlying insulin resistance are defects in insulin signaling through the protein kinase, Akt. Akt acts as a nodal point in the control of both the metabolic and pleiotropic effects of insulin. Imbalance among these effects leads to cardiac hypertrophy, fibrosis, and apoptosis; less angiogenesis; metabolic remodeling; and altered calcium cycling, all key features of uremic cardiomyopathy. Here we consider the role of Akt in the development of uremic cardiomyopathy, drawing parallels from models of hypertrophic cardiac disease.

Journal Article Type Review
Publication Date Feb 1, 2011
Print ISSN 1046-6673
Electronic ISSN 1533-3450
Publisher American Society of Nephrology
Peer Reviewed Peer Reviewed
Volume 22
Issue 2
Pages 207-215
APA6 Citation Semple, D., Smith, K., Bhandari, S., & Seymour, A. M. L. (2011). Uremic cardiomyopathy and insulin resistance: a critical role for Akt?. Journal of the American Society of Nephrology : JASN, 22(2), 207-215. doi:10.1681/ASN.2009090900
Keywords Nephrology; General Medicine