Uremic cardiomyopathy and insulin resistance: a critical role for Akt?

Semple, David; Smith, Katie; Bhandari, Sunil; Seymour, Anne Marie L.

Abstract

Uremic cardiomyopathy is a classic complication of chronic renal failure whose cause is unclear and treatment remains disappointing. Insulin resistance is an independent predictor of cardiovascular mortality in chronic renal failure. Underlying insulin resistance are defects in insulin signaling through the protein kinase, Akt. Akt acts as a nodal point in the control of both the metabolic and pleiotropic effects of insulin. Imbalance among these effects leads to cardiac hypertrophy, fibrosis, and apoptosis; less angiogenesis; metabolic remodeling; and altered calcium cycling, all key features of uremic cardiomyopathy. Here we consider the role of Akt in the development of uremic cardiomyopathy, drawing parallels from models of hypertrophic cardiac disease.

Citation

Semple, D., Smith, K., Bhandari, S., & Seymour, A. M. L. (2011). Uremic cardiomyopathy and insulin resistance: a critical role for Akt?. Journal of the American Society of Nephrology : JASN, 22(2), 207-215. doi:10.1681/ASN.2009090900

• Journal Article Type: Review
• Online Publication Date: Jul 15, 2010
• Publication Date: Feb 1, 2011
• Print ISSN: 1046-6673
• Electronic ISSN: 1533-3450
• Publisher: American Society of Nephrology
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 2
• Pages: 207-215
• DOI: https://doi.org/10.1681/ASN.2009090900
• Keywords: Nephrology; General Medicine
• Public URL: https://hull-repository.worktribe.com/output/417762