Uremic cardiomyopathy and insulin resistance: a critical role for Akt?
Semple, David; Smith, Katie; Bhandari, Sunil; Seymour, Anne Marie L.
Anne Marie L. Seymour A.M.Seymour@hull.ac.uk
Uremic cardiomyopathy is a classic complication of chronic renal failure whose cause is unclear and treatment remains disappointing. Insulin resistance is an independent predictor of cardiovascular mortality in chronic renal failure. Underlying insulin resistance are defects in insulin signaling through the protein kinase, Akt. Akt acts as a nodal point in the control of both the metabolic and pleiotropic effects of insulin. Imbalance among these effects leads to cardiac hypertrophy, fibrosis, and apoptosis; less angiogenesis; metabolic remodeling; and altered calcium cycling, all key features of uremic cardiomyopathy. Here we consider the role of Akt in the development of uremic cardiomyopathy, drawing parallels from models of hypertrophic cardiac disease.
|Journal Article Type||Review|
|Publication Date||Feb 1, 2011|
|Publisher||American Society of Nephrology|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Semple, D., Smith, K., Bhandari, S., & Seymour, A. M. L. (2011). Uremic cardiomyopathy and insulin resistance: a critical role for Akt?. Journal of the American Society of Nephrology : JASN, 22(2), 207-215. doi:10.1681/ASN.2009090900|
|Keywords||Nephrology; General Medicine|
You might also like
Uremic cardiomyopathy is characterised by loss of the cardioprotective effects of insulin
Functional and metabolic adaptation in uraemic cardiomyopathy