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Combinatorial microfluidic droplet engineering for biomimetic material synthesis

Meldrum, F. C.; McNally, C. S.; Demello, Andrew; Cho, S.; Niu, X.; Comyn, T. P.; Marchant, W. J.; Empson, C. J.; Bawazer, L. A.; Bawazer, Lukmaan A.; McNally, Ciara S.; Empson, Christopher J.; Marchant, William J.; Comyn, Tim P.; Niu, Xize; Cho, Soongwon; Mcpherson, Michael J.; Binks, Bernard P.; deMello, Andrew; Meldrum, Fiona C.

Authors

F. C. Meldrum

C. S. McNally

Andrew Demello

S. Cho

X. Niu

T. P. Comyn

W. J. Marchant

C. J. Empson

L. A. Bawazer

Lukmaan A. Bawazer

Ciara S. McNally

Christopher J. Empson

William J. Marchant

Tim P. Comyn

Xize Niu

Soongwon Cho

Michael J. Mcpherson

Andrew deMello

Fiona C. Meldrum



Abstract

Although droplet-based systems are used in a wide range of technologies, opportunities for systematically customizing their interface chemistries remain relatively unexplored. This article describes a new microfluidic strategy for rapidly tailoring emulsion droplet compositions and properties. The approach utilizes a simple platform for screening arrays of droplet-based microfluidic devices and couples this with combinatorial selection of the droplet compositions. Through the application of genetic algorithms over multiple screening rounds, droplets with target properties can be rapidly generated. The potential of this method is demonstrated by creating droplets with enhanced stability, where this is achieved by selecting carrier fluid chemistries that promote titanium dioxide formation at the droplet interfaces. The interface is a mixture of amorphous and crystalline phases, and the resulting composite droplets are biocompatible, supporting in vitro protein expression in their interiors. This general strategy will find widespread application in advancing emulsion properties for use in chemistry, biology, materials and medicine.

Journal Article Type Article
Publication Date Oct 7, 2016
Journal Science advances
Electronic ISSN 2375-2548
Publisher American Association for the Advancement of Science
Peer Reviewed Peer Reviewed
Volume 2
Issue 10
Article Number ARTN e1600567
Pages e1600567-e1600567
Institution Citation Bawazer, L. A., McNally, C. S., Empson, C. J., Marchant, W. J., Comyn, T. P., Niu, X., …Meldrum, F. C. (2016). Combinatorial microfluidic droplet engineering for biomimetic material synthesis. Science Advances, 2(10), e1600567-e1600567. doi:10.1126/sciadv.1600567
DOI https://doi.org/10.1126/sciadv.1600567
Keywords Droplet engineering
Publisher URL http://advances.sciencemag.org/content/2/10/e1600567
Copyright Statement Copyright © 2016, The Authors
This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Additional Information Copy of article first published in: Science advances, 2016, v.2, issue 10. Article no. e1600567

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Copyright Statement
Copyright © 2016, The Authors
This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.





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