Characterization of the metabolically healthy phenotype in overweight and obese British men

Ingle, Lee; Swainson, Michelle; Brodie, David; Sandercock, Gavin R.

Abstract

We calculated the prevalence of the metabolically healthy but obese (MHO) phenotype in (n=9 177) British men (age 48.9±7.4 years) attending preventive health screening between 2000 and 2009. We examined differences in cardiorespiratory fitness (Fitness) and self-reported physical activity levels, according to whether the men were metabolically healthy (<2 components of the metabolic syndrome), and by BMI category (normal-weight, over-weight, obese). Fitness was estimated from treadmill exercise as VO2peak and classified as: Low, Moderate, or High using age-specific cut-offs. We identified 21.6% of our sample as obese, of whom 83.1% were metabolically healthy. Compared with the metabolic unhealthy obese (MUO; 3.7% of sample), MHO phenotypes were fitter (effect size d=0.21) and were more physically active (d=0.31). Logistic regression showed high fitness (OR=2.40, 95%CI 1.38-4.19), and being physically active (OR=1.71, 95% CI 1.14-2.56) to be independently associated with the MHO phenotype. Our findings agree with US data suggesting that higher cardiorespiratory fitness is a characteristic of the MHO phenotype. Our finding that meeting physical activity guidelines was associated with the MHO phenotype independent of fitness is, however, novel. If confirmed, our findings indicate that public health messages that en-courage active lifestyles to promote fitness should be encouraged regardless of weight status.

Citation

Ingle, L., Swainson, M., Brodie, D., & Sandercock, G. R. (2017). Characterization of the metabolically healthy phenotype in overweight and obese British men. Preventive Medicine, 94, 7-11. https://doi.org/10.1016/j.ypmed.2016.11.001

• Journal Article Type: Article
• Acceptance Date: Nov 6, 2016
• Online Publication Date: Nov 10, 2016
• Publication Date: Jan 1, 2017
• Deposit Date: Nov 11, 2016
• Publicly Available Date: Nov 11, 2016
• Journal: Preventive medicine
• Print ISSN: 0091-7435
• Electronic ISSN: 1096-0260
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 94
• Pages: 7-11
• DOI: https://doi.org/10.1016/j.ypmed.2016.11.001
• Keywords: Cardiorespiratory fitness, Physical activity, Metabolic healthy, Metabolic unhealthy, Obesity, Metabolic syndrome
• Public URL: https://hull-repository.worktribe.com/output/445043
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0091743516303450
• Additional Information: This article is maintained by: Elsevier; Article Title: Characterization of the metabolically healthy phenotype in overweight and obese British men; Journal Title: Preventive Medicine; CrossRef DOI link to publisher maintained version: http://dx.doi.org/10.1016/j.ypmed.2016.11.001; Content Type: article; Copyright: © 2016 Elsevier Inc. All rights reserved.