Dag Aarsland
Nonlinear decline of mini-mental state examination in Parkinson's disease
Aarsland, Dag; Muniz, Graciela; Matthews, Fiona
Authors
Graciela Muniz
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
Abstract
The trajectory of cognitive functioning in patients with Parkinson's disease (PD) is not known. We used a random change point model to study the individual cognitive trajectory for up to 15 years in a prevalence sample of 238 PD patients, and used the mini-mental state examination (MMSE) to assess the longitudinal cognitive course. We observed that the rate of global cognitive decline was nonlinear. Following a relatively stable period, an inflection point was identified, after which the rate of decline gained momentum with an annual decline of 2.8 points on the MMSE. The course was similar in men and women. This inflection point was estimated to occur 13.3 years (95% credible interval 11.8, 13.6) after the diagnosis of PD; however, there were wide interindividual variations in the time from onset of PD to the inflection point. © 2010 Movement Disorder Society.
Citation
Aarsland, D., Muniz, G., & Matthews, F. (2011). Nonlinear decline of mini-mental state examination in Parkinson's disease. Movement Disorders, 26(2), 334-337. https://doi.org/10.1002/mds.23416
Journal Article Type | Article |
---|---|
Publication Date | Feb 1, 2011 |
Deposit Date | Dec 8, 2023 |
Journal | Movement Disorders |
Print ISSN | 0885-3185 |
Electronic ISSN | 1531-8257 |
Publisher | Wiley |
Volume | 26 |
Issue | 2 |
Pages | 334-337 |
DOI | https://doi.org/10.1002/mds.23416 |
Public URL | https://hull-repository.worktribe.com/output/4454926 |
You might also like
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search