A multichannel thiacalix[4]arene-based fluorescent chemosensor for Zn²⁺, F⁻ ions and imaging of living cells

Ran, Mao-Qian; Zhao, Jiang-Lin; Zhao, Yuan-Hui; Mou, Lan; Zeng, Xi; Redshaw, Carl; Yuan, Jian-Ying; Yamato, Takehiko

Abstract

The fluorescent sensor (3) based on the 1,3-alternate conformation of the thiacalix[4]arene bearing the coumarin fluorophore, appended via an imino group, has been synthesised. Sensing properties were evaluated in terms of a colorimetric and fluorescence sensor for Zn 2+ and F - . High selectivity and excellent sensitivity were exhibited, and off-on optical behaviour in different media was observed. All changes were visible to the naked eye, whilst the presence of the Zn 2+ and F - induces fluorescence enhancement and the formation of a 1:1 complex with 3. In addition, 3 exhibits low cytotoxicity and good cell permeability and can readily be employed for assessing the change of intracellular levels of Zn 2+ and F - .

Citation

Ran, M., Zhao, J., Zhao, Y., Mou, L., Zeng, X., Redshaw, C., …Yamato, T. (2016). A multichannel thiacalix[4]arene-based fluorescent chemosensor for Zn²⁺, F⁻ ions and imaging of living cells. Supramolecular chemistry, 28(5-6), 418-426. https://doi.org/10.1080/10610278.2015.1109645

• Journal Article Type: Article
• Acceptance Date: Oct 13, 2015
• Online Publication Date: Nov 18, 2015
• Publication Date: Jun 2, 2016
• Deposit Date: Dec 19, 2016
• Publicly Available Date: Dec 19, 2016
• Journal: Supramolecular chemistry
• Print ISSN: 1061-0278
• Electronic ISSN: 1029-0478
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 28
• Issue: 5-6
• Pages: 418-426
• DOI: https://doi.org/10.1080/10610278.2015.1109645
• Keywords: Thiacalix[4]arene derivative, Colorimetric and fluorescent sensor, Zn²⁺, F⁻, Cell imaging
• Public URL: https://hull-repository.worktribe.com/output/446181
• Publisher URL: http://www.tandfonline.com/doi/full/10.1080/10610278.2015.1109645
• Additional Information: Peer Review Statement: The publishing and review policy for this title is described in its Aims & Scope.; Aim & Scope: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=gsch20