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Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM<inf>2·5</inf> air pollution, 1990–2019: an analysis of data from the Global Burden of Disease Study 2019

Burkart, Katrin; Causey, Kate; Cohen, Aaron J.; Wozniak, Sarah S.; Salvi, Devashri Digvijay; Abbafati, Cristiana; Adekanmbi, Victor; Adsuar, Jose C.; Ahmadi, Keivan; Alahdab, Fares; Al-Aly, Ziyad; Alipour, Vahid; Alvis-Guzman, Nelson; Amegah, Adeladza Kofi; Andrei, Catalina Liliana; Andrei, Tudorel; Ansari, Fereshteh; Arabloo, Jalal; Aremu, Olatunde; Aripov, Timur; Babaee, Ebrahim; Banach, MacIej; Barnett, Anthony; Bärnighausen, Till Winfried; Bedi, Neeraj; Behzadifar, Masoud; Béjot, Yannick; Bennett, Derrick A.; Bensenor, Isabela M.; Bernstein, Robert S.; Bhattacharyya, Krittika; Bijani, Ali; Biondi, Antonio; Bohlouli, Somayeh; Breitner, Susanne; Brenner, Hermann; Butt, Zahid A.; Cámera, Luis Alberto; Cantu-Brito, Carlos; Carvalho, Felix; Cerin, Ester; Chattu, Vijay Kumar; Chauhan, Bal Govind; Choi, Jee Young Jasmine; Chu, Dinh Toi; Dai, Xiaochen; Dandona, Lalit; Dandona, Rakhi; Daryani, Ahmad; Davletov, Kairat; De Courten, Barbora; Demeke, Feleke Mekonnen; Denova-Gutiérrez, Edgar; Dh...

Authors

Katrin Burkart

Kate Causey

Aaron J. Cohen

Sarah S. Wozniak

Devashri Digvijay Salvi

Cristiana Abbafati

Victor Adekanmbi

Jose C. Adsuar

Keivan Ahmadi

Fares Alahdab

Ziyad Al-Aly

Vahid Alipour

Nelson Alvis-Guzman

Adeladza Kofi Amegah

Catalina Liliana Andrei

Tudorel Andrei

Fereshteh Ansari

Jalal Arabloo

Olatunde Aremu

Timur Aripov

Ebrahim Babaee

MacIej Banach

Anthony Barnett

Till Winfried Bärnighausen

Neeraj Bedi

Masoud Behzadifar

Yannick Béjot

Derrick A. Bennett

Isabela M. Bensenor

Robert S. Bernstein

Krittika Bhattacharyya

Ali Bijani

Antonio Biondi

Somayeh Bohlouli

Susanne Breitner

Hermann Brenner

Zahid A. Butt

Luis Alberto Cámera

Carlos Cantu-Brito

Felix Carvalho

Ester Cerin

Vijay Kumar Chattu

Bal Govind Chauhan

Jee Young Jasmine Choi

Dinh Toi Chu

Xiaochen Dai

Lalit Dandona

Rakhi Dandona

Ahmad Daryani

Kairat Davletov

Barbora De Courten

Feleke Mekonnen Demeke

Edgar Denova-Gutiérrez

Samath Dhamminda Dharmaratne

Meghnath Dhimal

Daniel Diaz

Shirin Djalalinia

Bruce B. Duncan

Maysaa El Sayed Zaki

Sharareh Eskandarieh

Mohammad Fareed

Farshad Farzadfar

Nazir Fattahi

Mehdi Fazlzadeh

Eduarda Fernandes

Irina Filip

Florian Fischer

Nataliya A. Foigt

Marisa Freitas

Ahmad Ghashghaee

Paramjit Singh Gill

Ibrahim Abdelmageed Ginawi

Sameer Vali Gopalani

Yuming Guo

Rajat Das Gupta

Tesfa Dejenie Habtewold

Randah R. Hamadeh

Samer Hamidi

Graeme J. Hankey

Edris Hasanpoor

Hamid Yimam Hassen

Simon I. Hay

Behzad Heibati

Michael K. Hole

Naznin Hossain

Mowafa Househ

Seyed Sina Naghibi Irvani

Jalil Jaafari

Mihajlo Jakovljevic

Ravi Prakash Jha

Jost B. Jonas

Jacek Jerzy Jozwiak

Amir Kasaeian

Neda Kaydi

Yousef Saleh Khader

Morteza Abdullatif Khafaie

Ejaz Ahmad Khan

Junaid Khan

Md Nuruzzaman Khan

Khaled Khatab



Abstract

Background: Experimental and epidemiological studies indicate an association between exposure to particulate matter (PM) air pollution and increased risk of type 2 diabetes. In view of the high and increasing prevalence of diabetes, we aimed to quantify the burden of type 2 diabetes attributable to PM2·5 originating from ambient and household air pollution. Methods: We systematically compiled all relevant cohort and case-control studies assessing the effect of exposure to household and ambient fine particulate matter (PM2·5) air pollution on type 2 diabetes incidence and mortality. We derived an exposure–response curve from the extracted relative risk estimates using the MR-BRT (meta-regression—Bayesian, regularised, trimmed) tool. The estimated curve was linked to ambient and household PM2·5 exposures from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, and estimates of the attributable burden (population attributable fractions and rates per 100 000 population of deaths and disability-adjusted life-years) for 204 countries from 1990 to 2019 were calculated. We also assessed the role of changes in exposure, population size, age, and type 2 diabetes incidence in the observed trend in PM2·5-attributable type 2 diabetes burden. All estimates are presented with 95% uncertainty intervals. Findings: In 2019, approximately a fifth of the global burden of type 2 diabetes was attributable to PM2·5 exposure, with an estimated 3·78 (95% uncertainty interval 2·68–4·83) deaths per 100 000 population and 167 (117–223) disability-adjusted life-years (DALYs) per 100 000 population. Approximately 13·4% (9·49–17·5) of deaths and 13·6% (9·73–17·9) of DALYs due to type 2 diabetes were contributed by ambient PM2·5, and 6·50% (4·22–9·53) of deaths and 5·92% (3·81–8·64) of DALYs by household air pollution. High burdens, in terms of numbers as well as rates, were estimated in Asia, sub-Saharan Africa, and South America. Since 1990, the attributable burden has increased by 50%, driven largely by population growth and ageing. Globally, the impact of reductions in household air pollution was largely offset by increased ambient PM2·5. Interpretation: Air pollution is a major risk factor for diabetes. We estimated that about a fifth of the global burden of type 2 diabetes is attributable PM2·5 pollution. Air pollution mitigation therefore might have an essential role in reducing the global disease burden resulting from type 2 diabetes. Funding: Bill & Melinda Gates Foundation.

Citation

Burkart, K., Causey, K., Cohen, A. J., Wozniak, S. S., Salvi, D. D., Abbafati, C., …Soyiri, I. (2022). Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2·5 air pollution, 1990–2019: an analysis of data from the Global Burden of Disease Study 2019. The Lancet Planetary Health, 6(7), e586-e600. https://doi.org/10.1016/S2542-5196%2822%2900122-X

Journal Article Type Article
Acceptance Date Jul 1, 2022
Online Publication Date Jul 6, 2022
Publication Date Jul 1, 2022
Deposit Date Jun 20, 2024
Publicly Available Date Jun 28, 2024
Journal The Lancet Planetary Health
Electronic ISSN 2542-5196
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 6
Issue 7
Pages e586-e600
DOI https://doi.org/10.1016/S2542-5196%2822%2900122-X
Public URL https://hull-repository.worktribe.com/output/4713725

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