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Synthesis of a novel HER2 targeted aza-BODIPY–antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation

Cheng, Miffy. H. Y.; Cheng, Miffy H.Y.; Maruani, Antoine; Savoie, Huguette; Chudasama, Vijay; Boyle, Ross. W.

Authors

Miffy. H. Y. Cheng

Miffy H.Y. Cheng

Antoine Maruani

Huguette Savoie

Vijay Chudasama



Abstract

We herein report the synthesis and analysis of a novel aza-BODIPY–antibody conjugate, formed by controlled and regioselective bioconjugation methodology. Employing the clinically relevant antibody, which targets HER2 positive cancers, represents the first example of an antibody targeting strategy for this class of near-IR emitting fluorophore. The NIR fluorescence and binding properties were validated through in vitro studies using live cell confocal imaging.

Citation

Cheng, M. H. Y., Cheng, M. H., Maruani, A., Savoie, H., Chudasama, V., & Boyle, R. W. (2018). Synthesis of a novel HER2 targeted aza-BODIPY–antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation. Organic & biomolecular chemistry, 16(7), 1144-1149. https://doi.org/10.1039/c7ob02957h

Journal Article Type Article
Acceptance Date Jan 16, 2018
Publication Date Jan 16, 2018
Deposit Date Jan 17, 2018
Publicly Available Date Jan 17, 2019
Journal Organic & biomolecular chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 16
Issue 7
Pages 1144-1149
DOI https://doi.org/10.1039/c7ob02957h
Keywords Physical and Theoretical Chemistry; Organic Chemistry; Biochemistry
Public URL https://hull-repository.worktribe.com/output/546953
Publisher URL http://pubs.rsc.org/en/content/articlelanding/2018/ob/c7ob02957h#!divAbstract
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Antoine Maruani (ORCID); : Antoine Maruani (ResearcherID); : Vijay Chudasama (ORCID); : Ross. W. Boyle (ORCID); : Single-blind; : Received 30 November 2017; Accepted 16 January 2018; Accepted Manuscript published 16 January 2018; Advance Article published 24 January 2018; Version of Record published 14 February 2018

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