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All Outputs (3)

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system (2023)
Journal Article
Barry, A., Samuel, S. F., Hosni, I., Moursi, A., Feugere, L., Sennett, C. J., Deepak, S., Achawal, S., Rajaraman, C., Iles, A., Wollenberg Valero, K. C., Scott, I. S., Green, V., Stead, L. F., Greenman, J., Wade, M. A., & Beltran-Alvarez, P. (2023). Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system. Lab on a chip, 23(11), 2664-2682. https://doi.org/10.1039/d3lc00204g

Arginine methylation is a post-translational modification that consists of the transfer of one or two methyl (CH3) groups to arginine residues in proteins. Several types of arginine methylation occur, namely monomethylation, symmetric dimethylation a... Read More about Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system.

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro (2021)
Journal Article
Collins, T., Pyne, E., Christensen, M., Iles, A., Pamme, N., & Pires, I. M. (2021). Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro. Biomicrofluidics, 15(4), Article 044103. https://doi.org/10.1063/5.0061373

The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D in vitro metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) remain an area of unmet need. Microfluidics allows us to introduce c... Read More about Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro.

A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings (2021)
Journal Article
Rodriguez-Mateos, P., Ngamsom, B., Walter, C., Dyer, C. E., Gitaka, J., Iles, A., & Pamme, N. (2021). A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings. Analytica Chimica Acta, 1177, Article 338758. https://doi.org/10.1016/j.aca.2021.338758

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the unprecedented global pandemic of coronavirus disease-2019 (COVID-19). Efforts are needed to develop rapid and accurate diagnostic tools for extensive testing, allowing for ef... Read More about A lab-on-a-chip platform for integrated extraction and detection of SARS-CoV-2 RNA in resource-limited settings.