All Outputs (4)

A small molecule MST1/2 inhibitor accelerates murine liver regeneration with improved survival in models of steatohepatitis (2024)
Journal Article
Watkins, R., Gamo, A., Choi, S. H., Kumar, M., Buckarma, E. L., McCabe, C., Tomlinson, J., Pereya, D., Lupse, B., Geravandi, S., Werneburg, N. W., Wang, C., Starlinger, P., Zhu, S., Li, S., Yu, S., Surakattula, M., Baguley, T., Ardestani, A., Maedler, K., …Smoot, R. (2024). A small molecule MST1/2 inhibitor accelerates murine liver regeneration with improved survival in models of steatohepatitis. PNAS Nexus, 3(3), Article pgae096. https://doi.org/10.1093/pnasnexus/pgae096

Dysfunctional liver regeneration following surgical resection remains a major cause of postoperative mortality and has no therapeutic options. Without targeted therapies, the current treatment paradigm relies on supportive therapy until homeostasis c... Read More about A small molecule MST1/2 inhibitor accelerates murine liver regeneration with improved survival in models of steatohepatitis.

Abnormal acinar–β-cell crosstalk in type 2 diabetes (2023)
Journal Article
Geravandi, S., & Ardestani, A. (2023). Abnormal acinar–β-cell crosstalk in type 2 diabetes. Trends in Endocrinology & Metabolism, 34(11), 685-687. https://doi.org/10.1016/j.tem.2023.08.006

Cellular crosstalk plays a vital role in maintaining pancreas homeostasis. Recently, in Cell Metabolism, Basile et al. demonstrated that aberrant upregulation of acinar-cell-specific pancreatic elastase CELA3B within endocrine islets reduces β-cell v... Read More about Abnormal acinar–β-cell crosstalk in type 2 diabetes.

How β cells can smell insulin fragments (2022)
Journal Article
Ardestani, A., & Maedler, K. (2022). How β cells can smell insulin fragments. Cell Metabolism, 34(2), 189-191. https://doi.org/10.1016/j.cmet.2022.01.003

In this issue of Cell Metabolism, Cheng et al. identify olfactory receptor Olfr109 in β cells with increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes. Binding of a small insulin fragment to Olfr109 fosters isle... Read More about How β cells can smell insulin fragments.

Hippo STK kinases drive metabolic derangement (2021)
Journal Article
Maedler, K., & Ardestani, A. (2021). Hippo STK kinases drive metabolic derangement. Nature Metabolism, 3(3), 295-296. https://doi.org/10.1038/s42255-021-00370-2

Obesity is associated with mitochondrial dysfunction and chronic metabolic derailment. Cho et al. report that elevated adipose expression of the Hippo kinases STK3 and STK4 (STK3/4) in obesity and type 2 diabetes decreases the mass and oxidative capa... Read More about Hippo STK kinases drive metabolic derangement.