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All Outputs (6)

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes (2016)
Journal Article
Yuan, T., Rafizadeh, S., Gorrepati, K. D. D., Lupse, B., Oberholzer, J., Maedler, K., & Ardestani, A. (2017). Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes. Diabetologia, 60(4), 668-678. https://doi.org/10.1007/s00125-016-4188-9

Aims/hypothesis: Mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of nutritional status at the cellular and organismic level. While mTORC1 mediates beta cell growth and expansion, its hyperactivation has been observed in pancr... Read More about Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes.

Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells (2016)
Journal Article
Yuan, T., Rafizadeh, S., Azizi, Z., Lupse, B., Devi Gorrepati, K. D., Awal, S., Oberholzer, J., Maedler, K., & Ardestani, A. (2016). Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells. JCI Insight, 1(18), Article e86326. https://doi.org/10.1172/jci.insight.86326

Loss of functional pancreatic β cells is a hallmark of both type 1 and 2 diabetes. Identifying the pathways that promote β cell proliferation and/or block β cell apoptosis is a potential strategy for diabetes therapy. The transcriptional coactivator... Read More about Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells.

Angiopoetin-2 signals do not mediate the hypervascularization of islets in type 2 diabetes (2016)
Journal Article
Shah, P., Lueschen, N., Ardestani, A., Oberholzer, J., Olerud, J., Carlsson, P. O., & Maedler, K. (2016). Angiopoetin-2 signals do not mediate the hypervascularization of islets in type 2 diabetes. PLoS ONE, 11(9), Article e0161834. https://doi.org/10.1371/journal.pone.0161834

Aims Changes in the islet vasculature have been implicated in the regulation of β-cell survival and function during the progression to type 2 diabetes (T2D). Failure of the β-cell to compensate for the increased insulin demand in obesity eventually l... Read More about Angiopoetin-2 signals do not mediate the hypervascularization of islets in type 2 diabetes.

β-MSCs: Successful fusion of MSCs with β-cells results in a β-cell like phenotype (2016)
Journal Article
Azizi, Z., Lange, C., Paroni, F., Ardestani, A., Meyer, A., Wu, Y., Zander, A. R., Westenfelder, C., & Maedler, K. (2016). β-MSCs: Successful fusion of MSCs with β-cells results in a β-cell like phenotype. Oncotarget, 7(31), 48963-48977. https://doi.org/10.18632/oncotarget.10214

Bone marrow mesenchymal stromal cells (MSC) have anti-inflammatory, antiapoptotic and immunosuppressive properties and are a potent source for cell therapy. Cell fusion has been proposed for rapid generation of functional new reprogrammed cells. In t... Read More about β-MSCs: Successful fusion of MSCs with β-cells results in a β-cell like phenotype.

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes (2016)
Journal Article
Ardestani, A., & Maedler, K. (2016). MST1: a promising therapeutic target to restore functional beta cell mass in diabetes. Diabetologia, 59(9), 1843-1849. https://doi.org/10.1007/s00125-016-3892-9

The loss of insulin-producing beta cells by apoptosis is a hallmark of all forms of diabetes mellitus. Strategies to prevent beta cell apoptosis and dysfunction are urgently needed to restore the insulin-producing cells and to prevent severe diabetes... Read More about MST1: a promising therapeutic target to restore functional beta cell mass in diabetes.