All Outputs (5)

mTORC1 and IRS1: Another Deadly Kiss (2018)
Journal Article
Ardestani, A., & Maedler, K. (2018). mTORC1 and IRS1: Another Deadly Kiss. Trends in Endocrinology & Metabolism, 29(11), 737-739. https://doi.org/10.1016/j.tem.2018.07.003

Mechanistic target of rapamycin complex (mTORC)1 is the major regulator of metabolism at the cellular and organismal level. mTORC1-mediated regulatory feedback loops enable adaptation to nutrient and growth factor availability and metabolic demand. I... Read More about mTORC1 and IRS1: Another Deadly Kiss.

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism (2018)
Journal Article
Ardestani, A., Lupse, B., & Maedler, K. (2018). Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism. Trends in Endocrinology & Metabolism, 29(7), 492-509. https://doi.org/10.1016/j.tem.2018.04.006

The evolutionarily conserved Hippo pathway is a key regulator of organ size and tissue homeostasis. Its dysregulation is linked to multiple pathological disorders. In addition to regulating development and growth, recent studies show that Hippo pathw... Read More about Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism.

An SCFfbxo28 E3 ligase protects pancreatic β-cells from apoptosis (2018)
Journal Article
Gorrepati, K. D. D., He, W., Lupse, B., Yuan, T., Maedler, K., & Ardestani, A. (2018). An SCFfbxo28 E3 ligase protects pancreatic β-cells from apoptosis. International Journal of Molecular Sciences, 19(4), Article 975. https://doi.org/10.3390/ijms19040975

Loss of pancreatic β-cell function and/or mass is a central hallmark of all forms of diabetes but its molecular basis is incompletely understood. β-cell apoptosis contributes to the reduced β-cell mass in diabetes. Therefore, the identification of im... Read More about An SCFfbxo28 E3 ligase protects pancreatic β-cells from apoptosis.

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response (2018)
Journal Article
Gorrepati, K. D. D., Lupse, B., Annamalai, K., Yuan, T., Maedler, K., & Ardestani, A. (2018). Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response. iScience, 1, 72-86. https://doi.org/10.1016/j.isci.2018.02.003

Impaired pancreatic β-cell survival contributes to the reduced β-cell mass in diabetes, but underlying regulatory mechanisms and key players in this process remain incompletely understood. Here, we identified the deubiquitinase ubiquitin-specific pro... Read More about Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response.

mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function (2018)
Journal Article
Yuan, T., Lupse, B., Maedler, K., & Ardestani, A. (2018). mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function. Journal of Molecular Biology, 430(7), 904-918. https://doi.org/10.1016/j.jmb.2018.02.013

The mechanistic target of rapamycin (mTOR) signaling pathway is an evolutionary conserved pathway that senses signals from nutrients and growth factors to regulate cell growth, metabolism and survival. mTOR acts in two biochemically and functionally... Read More about mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function.