Neratinib protects pancreatic beta cells in diabetes

Ardestani, Amin; Li, Sijia; Annamalai, Karthika; Lupse, Blaz; Geravandi, Shirin; Dobrowolski, Aleksandra; Yu, Shan; Zhu, Siying; Baguley, Tyler D.; Surakattula, Murali; Oetjen, Janina; Hauberg-Lotte, Lena; Herranz, Raquel; Awal, Sushil; Altenhofen, Delsi; Nguyen-Tran, Van; Joseph, Sean; Schultz, Peter G.; Chatterjee, Arnab K.; Rogers, Nikki; Tremblay, Matthew S.; Shen, Weijun; Maedler, Kathrin

doi:10.1038/s41467-019-12880-5

All Outputs (2)

Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes (2019)
Journal Article
Ardestani, A., Tremblay, M. S., Shen, W., & Maedler, K. (2019). Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes. Cell Death Discovery, 5(1), Article 149. https://doi.org/10.1038/s41420-019-0232-0

Neratinib protects pancreatic beta cells in diabetes (2019)
Journal Article
Ardestani, A., Li, S., Annamalai, K., Lupse, B., Geravandi, S., Dobrowolski, A., …Maedler, K. (2019). Neratinib protects pancreatic beta cells in diabetes. Nature communications, 10(1), Article 5015. https://doi.org/10.1038/s41467-019-12880-5

The loss of functional insulin-producing β-cells is a hallmark of diabetes. Mammalian sterile 20-like kinase 1 (MST1) is a key regulator of pancreatic β-cell death and dysfunction; its deficiency restores functional β-cells and normoglycemia. The ide... Read More about Neratinib protects pancreatic beta cells in diabetes.