All Outputs (3)

Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids (2020)
Journal Article
Ardestani, A., & Maedler, K. (2020). Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Frontiers in endocrinology, 11, Article 585922. https://doi.org/10.3389/fendo.2020.585922

STRIPAK Is a Regulatory Hub Initiating Hippo Signaling (2020)
Journal Article
Ardestani, A., & Maedler, K. (2020). STRIPAK Is a Regulatory Hub Initiating Hippo Signaling. Trends in Biochemical Sciences, 45(4), 280-283. https://doi.org/10.1016/j.tibs.2020.01.005

Signaling modules that integrate the diverse extra- and intracellular inputs to the Hippo pathway were previously unknown. By biochemical and molecular interrogation, Chen et al. established a molecular framework, the RhoA-RHPN-NF2/Kibra-STRIPAK axis... Read More about STRIPAK Is a Regulatory Hub Initiating Hippo Signaling.

Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance (2020)
Journal Article
Ardestani, A., & Maedler, K. (2020). Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance. Cell Metabolism, 31(1), 6-8. https://doi.org/10.1016/j.cmet.2019.12.006

In this issue of Cell Metabolism, El Ouarrat et al. identify the Hippo signaling terminal effector TAZ as an endogenous negative regulator of PPARγ, a master transcriptional regulator of lipid metabolism and insulin sensitivity. Selective destruction... Read More about Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance.