All Outputs (7)

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis (2021)
Journal Article
Yuan, T., Annamalai, K., Naik, S., Lupse, B., Geravandi, S., Pal, A., Dobrowolski, A., Ghawali, J., Ruhlandt, M., Gorrepati, K. D. D., Azizi, Z., Lim, D. S., Maedler, K., & Ardestani, A. (2021). The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nature communications, 12(1), Article 4928. https://doi.org/10.1038/s41467-021-25145-x

Diabetes results from a decline in functional pancreatic β-cells, but the molecular mechanisms underlying the pathological β-cell failure are poorly understood. Here we report that large-tumor suppressor 2 (LATS2), a core component of the Hippo signa... Read More about The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis.

Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes (2021)
Journal Article
Lupse, B., Annamalai, K., Ibrahim, H., Kaur, S., Geravandi, S., Sarma, B., Pal, A., Awal, S., Joshi, A., Rafizadeh, S., Madduri, M. K., Khazaei, M., Liu, H., Yuan, T., He, W., Gorrepati, K. D. D., Azizi, Z., Qi, Q., Ye, K., Oberholzer, J., …Ardestani, A. (2021). Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes. Cell reports, 36(5), Article 109490. https://doi.org/10.1016/j.celrep.2021.109490

Pancreatic β-cell failure is the key pathogenic element of the complex metabolic deterioration in type 2 diabetes (T2D); its underlying pathomechanism is still elusive. Here, we identify pleckstrin homology domain leucine-rich repeat protein phosphat... Read More about Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.

SARS-CoV-2 and pancreas: a potential pathological interaction? (2021)
Journal Article
Geravandi, S., Mahmoudi-aznaveh, A., Azizi, Z., Maedler, K., & Ardestani, A. (2021). SARS-CoV-2 and pancreas: a potential pathological interaction?. Trends in Endocrinology & Metabolism, 32(11), 842-845. https://doi.org/10.1016/j.tem.2021.07.004

The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into potential... Read More about SARS-CoV-2 and pancreas: a potential pathological interaction?.

LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes (2021)
Journal Article
Sanchez, P. K. M., Khazaei, M., Gatineau, E., Geravandi, S., Lupse, B., Liu, H., Dringen, R., Wojtusciszyn, A., Gilon, P., Maedler, K., & Ardestani, A. (2021). LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes. Biochemical and biophysical research communications, 568, 158-166. https://doi.org/10.1016/j.bbrc.2021.06.065

The lactate dehydrogenase isoform A (LDHA) is a key metabolic enzyme that preferentially catalyzes the conversion of pyruvate to lactate. Whereas LDHA is highly expressed in many tissues, its expression is turned off in the differentiated adult β-cel... Read More about LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes.

Targeting glucose metabolism for treatment of COVID-19 (2021)
Journal Article
Ardestani, A., & Azizi, Z. (2021). Targeting glucose metabolism for treatment of COVID-19. Signal Transduction and Targeted Therapy, 6(1), Article 112. https://doi.org/10.1038/s41392-021-00532-4

Hippo STK kinases drive metabolic derangement (2021)
Journal Article
Maedler, K., & Ardestani, A. (2021). Hippo STK kinases drive metabolic derangement. Nature Metabolism, 3(3), 295-296. https://doi.org/10.1038/s42255-021-00370-2

Obesity is associated with mitochondrial dysfunction and chronic metabolic derailment. Cho et al. report that elevated adipose expression of the Hippo kinases STK3 and STK4 (STK3/4) in obesity and type 2 diabetes decreases the mass and oxidative capa... Read More about Hippo STK kinases drive metabolic derangement.

Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy (2021)
Journal Article
Ardestani, A., & Maedler, K. (2021). Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy. Autophagy, 17(12), 4494-4496. https://doi.org/10.1080/15548627.2021.1972404

A progressive decline in the macroautophagic/autophagic flux is a hallmark of pancreatic β-cell failure in type 2 diabetes (T2D) but the responsible intrinsic factors and underlying molecular mechanisms are incompletely understood. A stress-sensitive... Read More about Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy.