All Outputs (4)

Case Report: Neratinib Therapy Improves Glycemic Control in a Patient With Type 2 Diabetes and Breast Cancer (2022)
Journal Article
Angelis, V., Johnston, S. R., Ardestani, A., & Maedler, K. (2022). Case Report: Neratinib Therapy Improves Glycemic Control in a Patient With Type 2 Diabetes and Breast Cancer. Frontiers in endocrinology, 13, Article 830097. https://doi.org/10.3389/fendo.2022.830097

A critical decline of functional insulin-producing pancreatic β-cells is the central pathologic element of both type 1 and type 2 diabetes. Mammalian Sterile 20-like kinase 1 (MST1) is a key mediator of β-cell failure and the identification of nerati... Read More about Case Report: Neratinib Therapy Improves Glycemic Control in a Patient With Type 2 Diabetes and Breast Cancer.

PHLPP1 deletion restores pancreatic β-cell survival and normoglycemia in the db/db mouse model of obesity-associated diabetes (2022)
Journal Article
Lupse, B., Heise, N., Maedler, K., & Ardestani, A. (2022). PHLPP1 deletion restores pancreatic β-cell survival and normoglycemia in the db/db mouse model of obesity-associated diabetes. Cell Death Discovery, 8(1), Article 57. https://doi.org/10.1038/s41420-022-00853-5

MST1 deletion protects β-cells in a mouse model of diabetes (2022)
Journal Article
Ardestani, A., & Maedler, K. (2022). MST1 deletion protects β-cells in a mouse model of diabetes. Nutrition and Diabetes, 12(1), Article 7. https://doi.org/10.1038/s41387-022-00186-3

The pro-apoptotic kinase Mammalian Sterile 20-like kinase 1 (MST1), an integral component of the Hippo pathway, is a key regulator of organ size, stress response, and tissue homeostasis; its aberrant hyperactivation is linked to multiple pathological... Read More about MST1 deletion protects β-cells in a mouse model of diabetes.

How β cells can smell insulin fragments (2022)
Journal Article
Ardestani, A., & Maedler, K. (2022). How β cells can smell insulin fragments. Cell Metabolism, 34(2), 189-191. https://doi.org/10.1016/j.cmet.2022.01.003

In this issue of Cell Metabolism, Cheng et al. identify olfactory receptor Olfr109 in β cells with increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes. Binding of a small insulin fragment to Olfr109 fosters isle... Read More about How β cells can smell insulin fragments.