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Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model (2018)
Journal Article
Oates, A., Lindsay, S., Mistry, H., Ortega, F., & McBain, A. J. (2018). Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model. Biofouling, 34(5), 507-518. doi:10.1080/08927014.2018.1466115

An in vitro model was developed to assess the effects of topical antimicrobials on taxonomically defined wound biofilms. Biofilms were exposed over seven days to povidone-iodine, silver acetate or polyhexamethylene biguanide (PHMB) at concentrations... Read More

Hyaluronan-based nanohydrogels for targeting intracellular S. Aureus in human keratinocytes (2018)
Journal Article
Montanari, E., Oates, A., Di Meo, C., Meade, J., Cerrone, R., Francioso, A., …Matricardi, P. (2018). Hyaluronan-based nanohydrogels for targeting intracellular S. Aureus in human keratinocytes. Advanced Healthcare Materials, 7(12), doi:10.1002/adhm.201701483

Staphylococcus aureus is one of the most significant human pathogens that is frequently isolated in a wide range of superficial and systemic infections. The ability of S. aureus to invade and survive within host cells such as keratinocytes and host i... Read More

Pursuing intracellular pathogens with Hyaluronan. From a ‘Pro-Infection’ polymer to a biomaterial for ‘Trojan Horse’ systems (2018)
Journal Article
Montanari, E., Di Meo, C., Oates, A., Coviello, T., & Matricardi, P. (2018). Pursuing intracellular pathogens with Hyaluronan. From a ‘Pro-Infection’ polymer to a biomaterial for ‘Trojan Horse’ systems. Molecules, 23(4), 939. doi:10.3390/molecules23040939

Hyaluronan (HA) is among the most important bioactive polymers in mammals, playing a key role in a number of biological functions. In the last decades, it has been increasingly studied as a biomaterial for drug delivery systems, thanks to its physico... Read More

The detrimental impact of extracellular bacterial proteases on wound healing: Bacterial proteases (2017)
Journal Article
Lindsay, S., Oates, A., & Bourdillon, K. (2017). The detrimental impact of extracellular bacterial proteases on wound healing: Bacterial proteases. International wound journal, 14(6), 1237-1247. doi:10.1111/iwj.12790

In addition to clinical signs of infection (e.g. inflammation, purulence and pain), a microbial count of ≥105 colony‐forming units/g has historically been used to define wound infection. However, it is increasingly recognised that, rather than a high... Read More

The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy methods (2014)
Journal Article
Oates, A., Bowling, F. L., Boulton, A. J. M., Bowler, P. G., Metcalf, D. G., & McBain, A. J. (2014). The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy methods. Journal of Diabetes Research, 2014, doi:10.1155/2014/153586

Diabetic foot wounds are commonly colonised by taxonomically diverse microbial communities and may additionally be infected with specific pathogens. Since biofilms are demonstrably less susceptible to antimicrobial agents than are planktonic bacteria... Read More