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Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse (2011)
Journal Article
Matsakas, A., Macharia, R., Otto, A., Elashry, M. I., Mouisel, E., Romanello, V., …Patel, K. (2012). Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse. Experimental Physiology, 97(1), 125-140. https://doi.org/10.1113/expphysiol.2011.063008

Myostatin regulates both muscle mass and muscle metabolism. The myostatin null (MSTN -/- ) mouse has a hypermuscular phenotype owing to both hypertrophy and hyperplasia of the myofibres. The enlarged muscles display a reliance on glycolysis for ener... Read More about Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse.