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Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease (2019)
Journal Article
Williams, H. F., Mellows, B. A., Mitchell, R., Sfyri, P., Layfield, H. J., Salamah, M., …Vaiyapuri, S. (2019). Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease. PLoS Neglected Tropical Diseases, 13(1), doi:10.1371/journal.pntd.0007041

Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year. Snakebite envenomation also causes innumerable morbidities specifically loss... Read More

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart (2019)
Journal Article
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., …Beltran-Alvarez, P. (in press). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology,

Background The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-tra... Read More

Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres (2019)
Journal Article
Omairi, S., Hau, K., Collins-Hooper, H., Scott, C., Vaiyapuri, S., Torelli, S., …Patel, K. (in press). Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres. Scientific reports,

The dystrophin-glycoprotein complex (DGC) links the muscle cytoskeleton to the extracellular matrix and is responsible for force transduction and protects the muscle fibres from contraction induced damage. Mutations in components of the DGC are respo... Read More

Platelet biology in regenerative medicine of skeletal muscle (2018)
Journal Article
Scully, D., Naseem, K. M., & Matsakas, A. (2018). Platelet biology in regenerative medicine of skeletal muscle. Acta Physiologica, 223(3), e13071. doi:10.1111/apha.13071

Platelet‐based applications such as platelet‐rich plasma (PRP) and platelet releasate have gained unprecedented attention in regenerative medicine across a variety of tissues as of late. The rationale behind utilizing PRP originates in the delivery o... Read More

The effect of caloric restriction on the forelimb skeletal muscle fibers of the hypertrophic myostatin null mice (2017)
Journal Article
Elashry, M. I., Matsakas, A., Arnhold, S., Elashry, M., Patel, K., & Wenisch, S. (2017). The effect of caloric restriction on the forelimb skeletal muscle fibers of the hypertrophic myostatin null mice. Acta Histochemica, 119(5), (582-591). doi:10.1016/j.acthis.2017.06.002. ISSN 0065-1281

Skeletal muscle mass loss has a broad impact on body performance and physical activity. Muscle wasting occurs due to genetic mutation as in muscular dystrophy, age-related muscle loss (sarcopenia) as well as in chronic wasting disorders as in cancer... Read More

Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres (2016)
Journal Article
Omairi, S., Matsakas, A., Degens, H., Kretz, O., Hansson, K., Solbrå, A. V., …Patel, K. (2016). Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. eLife, 5, doi:10.7554/eLife.16940

A central tenet of skeletal muscle biology is the existence of an inverse relationship between the oxidative fibre capacity and its size. However, robustness of this relationship is unknown. We show that superimposition of Estrogen-related receptor g... Read More

PGC1β activates an antiangiogenic program to repress neoangiogenesis in muscle ischemia (2014)
Journal Article
Yadav, V., Matsakas, A., Lorca, S., & Narkar, V. A. (2014). PGC1β activates an antiangiogenic program to repress neoangiogenesis in muscle ischemia. Cell reports, 8(3), (783-797). doi:10.1016/j.celrep.2014.06.040. ISSN 2211-1247

Revascularization of ischemic skeletalmuscle is governed by a balance between pro- and antiangiogenic factors in multiple cell types but particularly in myocytes and endothelial cells. Whereas the regulators of proangiogenic factors are well defined... Read More

Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming (2013)
Journal Article
Matsakas, A., Yadav, V., Lorca, S., & Narkar, V. (2013). Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming. FASEB Journal, 27(10), 4004-4016. doi:10.1096/fj.13-228296

Treatment of Duchenne muscular dystrophy (DMD) by replacing mutant dystrophin or restoring dystrophin-associated glycoprotein complex (DAG) has been clinically challenging. Instead, identifying and targeting muscle pathways deregulated in DMD will pr... Read More

Revascularization of ischemic skeletal muscle by estrogen-related receptor-gamma (2012)
Journal Article
Matsakas, A., Evans, R., Lorca, S., Narkar, V., & Yadav, V. (2012). Revascularization of ischemic skeletal muscle by estrogen-related receptor-gamma. Circulation Research, 110(8), 1087-1096. doi:10.1161/CIRCRESAHA.112.266478

RATIONALE Oxidative myofibers in the skeletal muscles express high levels of angiogenic factors, have dense vasculature, and promptly revascularize during ischemia. Estrogen-related receptor-gamma (ERRγ) activates genes that govern metabolic and vasc... Read More

Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse (2010)
Journal Article
Patel, K., Brown, S. C., Elashry, M. I., Otto, A., & Matsakas, A. (2010). Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse. Rejuvenation Research, 13(6), 717-727. doi:10.1089/rej.2010.1065

Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse a... Read More

Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise (2010)
Journal Article
Patel, K., Amthor, H., Mouisel, E., & Matsakas, A. (2010). Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise. Journal of Muscle Research and Cell Motility, 31(2), 111-125. doi:10.1007/s10974-010-9214-9

Myostatin-deficient mice (MSTN (-/-)) display excessive muscle mass and this is associated with a profound loss of oxidative metabolic properties. In this study we analysed the effect of two endurance-based exercise regimes, either a forced high-impa... Read More