Skip to main content

Research Repository

Advanced Search

Combined Metallomics/ Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair (2021)
Journal Article
Wilkinson, H. N., Guinn, B., & Hardman, M. J. (2021). Combined Metallomics/ Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair. Frontiers in Cell and Developmental Biology, 9, https://doi.org/10.3389/fcell.2021.788596

Endogenous metals are required for all life, orchestrating the action of diverse cellular processes that are crucial for tissue function. The dynamic wound healing response is underpinned by a plethora of such cellular behaviours, occurring in a time... Read More about Combined Metallomics/ Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair.

Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients (2021)
Journal Article
Dӧhner, H., Greiner, J., Brown, E., Bullinger, L., Hills, R. K., Morris, V., …Guinn, B. A. (2021). Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients. International Journal of Molecular Sciences, 22(19), https://doi.org/10.3390/ijms221910482

Abstract: Despite recent advances in therapies including immunotherapy, patients with acute myeloid leukaemia (AML) still experience relatively poor survival rates. The Inhibition of Apoptosis (IAP) family member, survivin, also known by its gene and... Read More about Survivin’ acute myeloid leukaemia—a personalised target for inv(16) patients.

Survivin’ Acute Myeloid Leukaemia –a personalised target for inv(16) patients (2021)
Journal Article
Greiner, J., Brown, E., Bullinger, L., Hills, R., Morris, V., Dohner, H., …Guinn, B. (2021). Survivin’ Acute Myeloid Leukaemia –a personalised target for inv(16) patients. International Journal of Molecular Sciences, 22(19), https://doi.org/10.3390/ijms221910482

Despite recent advances in therapies including immunotherapy, patients with acute myeloid leukaemia (AML) still experience relatively poor survival rates. The Inhibition of Apoptosis (IAP) family member, Survivin, also known by its gene and protein n... Read More about Survivin’ Acute Myeloid Leukaemia –a personalised target for inv(16) patients.

Inhibition of arginine methylation impairs platelet function (2021)
Journal Article
Marsden, A. J., Riley, D. R. J., Barry, A., Khalil, J. S., Guinn, B. A., Kemp, N. T., …Beltran-Alvarez, P. (in press). Inhibition of arginine methylation impairs platelet function. ACS Pharmacology & Translational Science, https://doi.org/10.1021/acsptsci.1c00135

Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to arginine residues in proteins. PRMT inhibitors are novel, promising drugs against cancer that are currently in clinical trials, which include oral administration of... Read More about Inhibition of arginine methylation impairs platelet function.

Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers (2021)
Journal Article
Marsden, A. J., Riley, D. R., Birkett, S., Rodriguez-Barucg, Q., Guinn, B. A., Carroll, S., …Beltran-Alvarez, P. (in press). Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers. Amino acids, https://doi.org/10.1007/s00726-021-03024-5

Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily av... Read More about Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.

A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone (2021)
Journal Article
Almshayakhchi, R., Nagarajan, D., Vadakekolathu, J., Guinn, B. A., Reeder, S., Brentville, V., …McArdle, S. (2021). A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone. Frontiers in Oncology, 11, https://doi.org/10.3389/fonc.2021.636977

Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms’ tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody® vaccines derived T-cells can kill ex-vivo human CML cell lines expre... Read More about A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone.

Identification of Genes Whose Expression Overlaps Age Boundaries and Correlates with Risk Groups in Paediatric and Adult Acute Myeloid Leukaemia (2020)
Journal Article
Davis, L., Mills, K. I., Orchard, K. H., & Guinn, B. A. (2020). Identification of Genes Whose Expression Overlaps Age Boundaries and Correlates with Risk Groups in Paediatric and Adult Acute Myeloid Leukaemia. Cancers, 12(10), 1-22. https://doi.org/10.3390/cancers12102769

Few studies have compared gene expression in paediatric and adult acute myeloid leukaemia (AML). In this study, we have analysed mRNA-sequencing data from two publicly accessible databases: (1) National Cancer Institute's Therapeutically Applicable R... Read More about Identification of Genes Whose Expression Overlaps Age Boundaries and Correlates with Risk Groups in Paediatric and Adult Acute Myeloid Leukaemia.

Serum-profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia (2020)
Journal Article
Jordaens, S., Cooksey, L., Bonney, S., Orchard, L., Coutinho, M., Van Tendeloo, V., …Guinn, B. (2020). Serum-profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia. British journal of haematology, 189(3), 500-512. https://doi.org/10.1111/bjh.16407

Acute lymphoblastic leukaemia (ALL) is a haematological malignancy that is characterized by the uncontrolled proliferation of immature lymphocytes. 80 % of cases occur in children where ALL is well understood and treated. However it has a devastating... Read More about Serum-profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia.

New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia (2020)
Journal Article
Jordaens, S., Cooksey, L., Freire Boullosa, L., Van Tendeloo, V., Smits, E., Mills, K. I., …Guinn, B. A. (2020). New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia. Cancer Immunology, Immunotherapy, 69(5), 867-877. https://doi.org/10.1007/s00262-020-02484-0

Acute lymphoblastic leukaemia (ALL) in adults is a rare and difficult-to-treat cancer that is characterised by excess lymphoblasts in the bone marrow. Although many patients achieve remission with chemotherapy, relapse rates are high and the associat... Read More about New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia.

Retrospective Medical Record Research: Reflections of A Unsponsored Researcher (2019)
Journal Article
Bature, F., Guinn, B., Vseteckova, J., Pang, D., & Pappas, Y. (2019). Retrospective Medical Record Research: Reflections of A Unsponsored Researcher. Biomedical Journal of Scientific & Technical Research, 21(4), 16080-16086. https://doi.org/10.26717/BJSTR.2019.21.003642

This article is a reflective narrative by the author following the successful completion of a doctoral thesis involving the analysis of primary care data. The aim of the study was to identify patterns in signs and symptoms preceding a clinical diagno... Read More about Retrospective Medical Record Research: Reflections of A Unsponsored Researcher.

Urine biomarkers for the early detection of ovarian cancer – are we there yet? (2019)
Journal Article
Grayson, K., Gregory, E., Khan, G., & Guinn, B. (2019). Urine biomarkers for the early detection of ovarian cancer – are we there yet?. Biomarkers in Cancer, 11, https://doi.org/10.1177/1179299x19830977

Ovarian cancer affects around 7500 women in the United Kingdom every year. Despite this, there is no effective screening strategy or standard treatment for ovarian cancer. If diagnosed during stage I, ovarian cancer has a 90% 5-year survival rate; ho... Read More about Urine biomarkers for the early detection of ovarian cancer – are we there yet?.

Antigenic targets for the immunotherapy of acute myeloid leukaemia (2019)
Journal Article
Khan, G. N., Khan, G., Orchard, K., & Guinn, B. A. (2019). Antigenic targets for the immunotherapy of acute myeloid leukaemia. Journal of Clinical Medicine, 8(2), 134. https://doi.org/10.3390/jcm8020134

One of the most promising approaches to preventing relapse is the stimulation of the body’s own immune system to kill residual cancer cells after conventional therapy has destroyed the bulk of the tumour. In acute myeloid leukaemia (AML), the high fr... Read More about Antigenic targets for the immunotherapy of acute myeloid leukaemia.

Perspectives of General Practitioners on the issues surrounding the late diagnosis of Alzheimer’s disease (2018)
Journal Article
Bature, F., Guinn, B., Pang, D., The Luton, Dunstable, Milton Keynes General Practise consortium, , & Pappas, Y. (2018). Perspectives of General Practitioners on the issues surrounding the late diagnosis of Alzheimer’s disease. Journal of Alzheimer's Disease Reports, 2(1), 207-212. https://doi.org/10.3233/adr-180064

We set out to investigate the insights general practitioners (GPs) have into the early signs and symptoms of Alzheimer's disease (AD), factors that may be responsible for the late diagnosis, as well as their recommendations for early diagnosis of AD.... Read More about Perspectives of General Practitioners on the issues surrounding the late diagnosis of Alzheimer’s disease.

Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design (2018)
Journal Article
Bature, F., Pang, D., Robinson, A., Polson, N., Pappas, Y., & Guinn, B. (2018). Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design. Current Alzheimer Research, 15(8), 723-730. https://doi.org/10.2174/1567205015666180404155358

Objective: Evidence suggests that individuals with Alzheimer’s disease (AD) are often diagnosed in the later stages of their disease with a poor prognosis. This study is aimed to identify patterns in signs and symptoms preceding the clinical diagnosi... Read More about Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design.

Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia (2017)
Journal Article
Boullosa, L. F., Savaliya, P., Bonney, S., Orchard, L., Wickenden, H., Lee, C., …Guinn, B. A. (2018). Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia. Oncotarget, 9(3), 3853-3866. https://doi.org/10.18632/oncotarget.23380

B-cell acute lymphoblastic leukemia (B-ALL) is a rare heterogeneous disease characterized by a block in lymphoid differentiation and a rapid clonal expansion of immature, non-functioning B cells. Adult B-ALL patients have a poor prognosis with less t... Read More about Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia.

Signs and symptoms preceding the diagnosis of Alzheimer's disease: A systematic scoping review of literature from 1937 to 2016 (2017)
Journal Article
Bature, F., Guinn, B. A., Pang, D., & Pappas, Y. (2017). Signs and symptoms preceding the diagnosis of Alzheimer's disease: A systematic scoping review of literature from 1937 to 2016. BMJ open, 7(8), https://doi.org/10.1136/bmjopen-2016-015746

OBJECTIVE: Late diagnosis of Alzheimer's disease (AD) may be due to diagnostic uncertainties. We aimed to determine the sequence and timing of the appearance of established early signs and symptoms in people who are subsequently diagnosed with AD.... Read More about Signs and symptoms preceding the diagnosis of Alzheimer's disease: A systematic scoping review of literature from 1937 to 2016.

Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis (2015)
Journal Article
Brooks, S. E., Bonney, S. A., Lee, C., Publicover, A., Khan, G., Smits, E. L., …Guinn, B. A. (2015). Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis. PLoS ONE, 10(10), https://doi.org/10.1371/journal.pone.0140483

Immunotherapy treatments for cancer are becoming increasingly successful, however to further improve our understanding of the T-cell recognition involved in effective responses and to encourage moves towards the development of personalised treatments... Read More about Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis.

Analogue peptides for the immunotherapy of human acute myeloid leukemia (2015)
Journal Article
Hofmann, S., Mead, A., Malinovskis, A., Hardwick, N. R., & Guinn, B. A. (2015). Analogue peptides for the immunotherapy of human acute myeloid leukemia. Cancer Immunology, Immunotherapy, 64(11), 1357-1367. https://doi.org/10.1007/s00262-015-1762-9

The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the i... Read More about Analogue peptides for the immunotherapy of human acute myeloid leukemia.

A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells (2015)
Journal Article
Collin, J. F., Wells, J. W., Czepulkowski, B., Lyne, L., Duriez, P. J., Banham, A. H., …Guinn, B. A. (2015). A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells. Genes, Chromosomes and Cancer, 54(5), 288-302. https://doi.org/10.1002/gcc.22242

To increase our knowledge of leukaemia‐associated antigens, especially in acute myeloid leukaemia (AML) M4, we prepared a phage display cDNA library using mRNA from the bone marrow cells of a patient with AML M4 at diagnosis. We immunoscreened 106 pf... Read More about A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells.