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Azithromycin for sarcoidosis cough: an open label exploratory clinical trial (2020)
Journal Article
Fraser, S. D., Thackray-Nocera, S., Shepherd, M., Flockton, R., Wright, C., Sheedy, W., …Hart, S. P. (in press). Azithromycin for sarcoidosis cough: an open label exploratory clinical trial. ERJ Open Research, https://doi.org/10.1183/23120541.00534-2020

Background Chronic cough is a distressing symptom for many people with pulmonary sarcoidosis. Continuous treatment with a macrolide antibiotic may improve cough. We aimed to assess the potential efficacy of azithromycin in patients with sarcoidosis a... Read More about Azithromycin for sarcoidosis cough: an open label exploratory clinical trial.

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol (2019)
Journal Article
Crooks, M. G., Wright, C., Hart, S. P., Allgar, V., English, A., Swan, F., …Crooks, M. G. (2019). A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol. ERJ Open Research, 5(4), https://doi.org/10.1183/23120541.00186-2019

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now av... Read More about A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol.

The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study (2019)
Journal Article
Morice, A. H., Kitt, M. M., Ford, A. P., Tershakovec, A. M., Wu, W., Brindle, K., …Wright, C. (2019). The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study. The European respiratory journal, 54(1), https://doi.org/10.1183/13993003.00439-2019

We evaluated the effect of gefapixant on cough reflex sensitivity to evoked tussive challenge. In this phase 2, double-blind, two-period study, patients with chronic cough (CC) and healthy volunteers (HV) were randomised to single-dose gefapixant... Read More about The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study.

Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation (2017)
Journal Article
Crooks, M. G., den Brinker, A., Hayman, Y., Williamson, J. D., Innes, A., Wright, C. E., …Morice, A. H. (2017). Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation. Lung, 195(3), 289-294. https://doi.org/10.1007/s00408-017-9996-2

Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deteriorat... Read More about Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation.

TRPV1 polymorphisms influence capsaicin cough sensitivity in men (2017)
Journal Article
Sadofsky, L. R., Cantero-Recasens, G., Wright, C., Valverde, M. A., & Morice, A. H. (2017). TRPV1 polymorphisms influence capsaicin cough sensitivity in men. Journal of thoracic disease, 9(3), 839-840. doi:10.21037/jtd.2017.03.50

Capsaicin, the hot component of chilli peppers, is a well-known tussive agent, which is regularly used as a tool to study cough and antitussives (1). Capsaicin is known to activate the transient receptor potential vanilloid 1 (TRPV1) cation channel w... Read More about TRPV1 polymorphisms influence capsaicin cough sensitivity in men.

Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity? (2017)
Journal Article
Fowles, H. E., Rowland, T., Wright, C., & Morice, A. (2017). Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?. The European respiratory journal, 49(2), https://doi.org/10.1183/13993003.01452-2016

Recent studies have demonstrated that blockade of P2X3 adenosine triphosphate (ATP) receptors may profoundly inhibit chronic cough. We have considered whether inhaled ATP produces a tussive response and whether chronic cough patients are hypersensiti... Read More about Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. doi:10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

The online Cough Clinic: Developing guideline-based diagnosis and advice (2009)
Journal Article
Dettmar, P. W., Strugala, V., Fathi, H., Dettmar, H. J., Wright, C., & Morice, A. H. (2009). The online Cough Clinic: Developing guideline-based diagnosis and advice. The European respiratory journal, 34(4), 819-824. doi:10.1183/09031936.00126908

The aim of the present study was make chronic cough guidelines more practical and user friendly by developing an internet-based interactive diagnostic questionnaire for chronic cough. A prospective cohort study of chronic cough sufferers was conducte... Read More about The online Cough Clinic: Developing guideline-based diagnosis and advice.


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